Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women

BACKGROUND: Rheumatoid arthritis (RA) preferentially affects women, with the peak incidence coinciding with estrogen decrease in menopause. Estrogen (E2) may therefore have intrinsic immune-regulatory properties that vanish with menopause. Fc sialylation is a crucial factor determining the inflammat...

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Detalles Bibliográficos
Autores principales: Engdahl, Cecilia, Bondt, Albert, Harre, Ulrike, Raufer, Jasmin, Pfeifle, René, Camponeschi, Alessandro, Wuhrer, Manfred, Seeling, Michaela, Mårtensson, Inga-Lill, Nimmerjahn, Falk, Krönke, Gerhard, Scherer, Hans U., Forsblad-d’Elia, Helena, Schett, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932893/
https://www.ncbi.nlm.nih.gov/pubmed/29720252
http://dx.doi.org/10.1186/s13075-018-1586-z

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