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“Phage Transplantation in Allotransplantation”: Possible Treatment in Graft-Versus-Host Disease?

Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial r...

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Detalles Bibliográficos
Autores principales: Górski, Andrzej, Jończyk-Matysiak, Ewa, Międzybrodzki, Ryszard, Weber-Dąbrowska, Beata, Borysowski, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933259/
https://www.ncbi.nlm.nih.gov/pubmed/29755481
http://dx.doi.org/10.3389/fimmu.2018.00941
Descripción
Sumario:Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial resistance has greatly revived interest in using bacterial viruses (phages) to combat antibiotic-resistant bacteria. In recent years, evidence has accumulated indicating that phages also have anti-inflammatory and immunomodulatory activities. This article suggests how these anti-bacterial and immunomodulatory activities of phages may be translated into a novel treatment of acute GvHD.