Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: In 15 coh...

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Detalles Bibliográficos
Autores principales: Andersen, Zorana J., Stafoggia, Massimo, Weinmayr, Gudrun, Pedersen, Marie, Galassi, Claudia, Jørgensen, Jeanette T., Oudin, Anna, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Marit Aasvang, Gunn, Aamodt, Geir, Pyko, Andrei, Pershagen, Göran, Korek, Michal, De Faire, Ulf, Pedersen, Nancy L., Östenson, Claes-Göran, Fratiglioni, Laura, Eriksen, Kirsten T., Tjønneland, Anne, Peeters, Petra H., Bueno-de-Mesquita, Bas, Plusquin, Michelle, Key, Timothy J., Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Fournier, Agnes, Boutron-Ruault, Marie-Christine, Baglietto, Laura, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Tamayo-Uria, Ibon, Amiano, Pilar, Dorronsoro, Miren, Vermeulen, Roel, Sokhi, Ranjeet, Keuken, Menno, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933325/
https://www.ncbi.nlm.nih.gov/pubmed/29033383
http://dx.doi.org/10.1289/EHP1742
Descripción
Sumario:BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts - Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) [Formula: see text] , [Formula: see text] , and [Formula: see text] in diameter ([Formula: see text] , [Formula: see text] , and [Formula: see text] , respectively); [Formula: see text] absorbance; nitrogen oxides ([Formula: see text] and [Formula: see text]); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses. RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and [Formula: see text] {hazard ratio [Formula: see text] [95% confidence interval (CI): 0.77, 1.51] per [Formula: see text]}, [Formula: see text] [1.07 (95% CI: 0.89, 1.30) per [Formula: see text]], [Formula: see text] [1.20 (95% CI: 0.96, 1.49 per [Formula: see text]], and [Formula: see text] [1.02 (95% CI: 0.98, 1.07 per [Formula: see text]], and a statistically significant association with [Formula: see text] [1.04 (95% CI: 1.00, 1.08) per [Formula: see text] , [Formula: see text]]. CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women. https://doi.org/10.1289/EHP1742

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