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Fluorinated Eu(II)-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging

Magnetic resonance imaging (MRI) using redox-active, Eu(II)-containing complexes is one of the most promising techniques for noninvasively imaging hypoxia in vivo. In this technique, positive (T(1)-weighted) contrast enhancement persists in areas of relatively low oxidizing ability, such as hypoxic...

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Detalles Bibliográficos
Autores principales: Basal, Lina A., Bailey, Matthew D., Romero, Jonathan, Ali, Meser M., Kurenbekova, Lyazat, Yustein, Jason, Pautler, Robia G., Allen, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933353/
https://www.ncbi.nlm.nih.gov/pubmed/29780447
http://dx.doi.org/10.1039/c7sc03142d
Descripción
Sumario:Magnetic resonance imaging (MRI) using redox-active, Eu(II)-containing complexes is one of the most promising techniques for noninvasively imaging hypoxia in vivo. In this technique, positive (T(1)-weighted) contrast enhancement persists in areas of relatively low oxidizing ability, such as hypoxic tissue. Herein, we describe a fluorinated, Eu(II)-containing complex in which the redox-active metal is caged by intramolecular interactions. The position of the fluorine atoms enables temperature-responsive contrast enhancement in the reduced form of the contrast agent and detection of the oxidized contrast agent via MRI in vivo. Positive contrast is observed in (1)H-MRI with Eu in the +2 oxidation state, and chemical exchange saturation transfer and (19)F-MRI signal are observed with Eu in the +3 oxidation state. Contrast enhancement is controlled by the redox state of Eu, and modulated by the fluorous interactions that cage a bound water molecule reduce relaxivity in a temperature-dependent fashion. Together, these advancements constitute the first report of in vivo, redox-responsive imaging using (19)F-MRI.