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Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort

BACKGROUND: Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD). OBJECTIVES: We conducted a nes...

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Autores principales: Yuan, Yu, Xiao, Yang, Feng, Wei, Liu, Yiyi, Yu, Yanqiu, Zhou, Lue, Qiu, Gaokun, Wang, Hao, Liu, Bing, Liu, Kang, Yang, Handong, Li, Xiulou, Min, Xinwen, Zhang, Ce, Xu, Chengwei, Zhang, Xiaomin, He, Meian, Hu, Frank B., Pan, An, Wu, Tangchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933370/
https://www.ncbi.nlm.nih.gov/pubmed/29064788
http://dx.doi.org/10.1289/EHP1521
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author Yuan, Yu
Xiao, Yang
Feng, Wei
Liu, Yiyi
Yu, Yanqiu
Zhou, Lue
Qiu, Gaokun
Wang, Hao
Liu, Bing
Liu, Kang
Yang, Handong
Li, Xiulou
Min, Xinwen
Zhang, Ce
Xu, Chengwei
Zhang, Xiaomin
He, Meian
Hu, Frank B.
Pan, An
Wu, Tangchun
author_facet Yuan, Yu
Xiao, Yang
Feng, Wei
Liu, Yiyi
Yu, Yanqiu
Zhou, Lue
Qiu, Gaokun
Wang, Hao
Liu, Bing
Liu, Kang
Yang, Handong
Li, Xiulou
Min, Xinwen
Zhang, Ce
Xu, Chengwei
Zhang, Xiaomin
He, Meian
Hu, Frank B.
Pan, An
Wu, Tangchun
author_sort Yuan, Yu
collection PubMed
description BACKGROUND: Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD). OBJECTIVES: We conducted a nested case–control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD. METHODS: A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age ([Formula: see text]) and sex. We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHD for metal concentrations categorized according to quartiles in controls. RESULTS: Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from single-metal multivariable models adjusted for established cardiovascular risk factors. When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69; [Formula: see text]), 1.78 (95% CI: 1.29, 2.46; [Formula: see text]), and 0.67 (95% CI: 0.52, 0.85; [Formula: see text]), respectively. CONCLUSIONS: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521
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spelling pubmed-59333702018-05-10 Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort Yuan, Yu Xiao, Yang Feng, Wei Liu, Yiyi Yu, Yanqiu Zhou, Lue Qiu, Gaokun Wang, Hao Liu, Bing Liu, Kang Yang, Handong Li, Xiulou Min, Xinwen Zhang, Ce Xu, Chengwei Zhang, Xiaomin He, Meian Hu, Frank B. Pan, An Wu, Tangchun Environ Health Perspect Research BACKGROUND: Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD). OBJECTIVES: We conducted a nested case–control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD. METHODS: A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age ([Formula: see text]) and sex. We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHD for metal concentrations categorized according to quartiles in controls. RESULTS: Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from single-metal multivariable models adjusted for established cardiovascular risk factors. When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69; [Formula: see text]), 1.78 (95% CI: 1.29, 2.46; [Formula: see text]), and 0.67 (95% CI: 0.52, 0.85; [Formula: see text]), respectively. CONCLUSIONS: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521 Environmental Health Perspectives 2017-10-19 /pmc/articles/PMC5933370/ /pubmed/29064788 http://dx.doi.org/10.1289/EHP1521 Text en EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
spellingShingle Research
Yuan, Yu
Xiao, Yang
Feng, Wei
Liu, Yiyi
Yu, Yanqiu
Zhou, Lue
Qiu, Gaokun
Wang, Hao
Liu, Bing
Liu, Kang
Yang, Handong
Li, Xiulou
Min, Xinwen
Zhang, Ce
Xu, Chengwei
Zhang, Xiaomin
He, Meian
Hu, Frank B.
Pan, An
Wu, Tangchun
Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
title Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
title_full Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
title_fullStr Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
title_full_unstemmed Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
title_short Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
title_sort plasma metal concentrations and incident coronary heart disease in chinese adults: the dongfeng-tongji cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933370/
https://www.ncbi.nlm.nih.gov/pubmed/29064788
http://dx.doi.org/10.1289/EHP1521
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