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Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study

BACKGROUND: Ethnic minority individuals have an increased risk of developing a psychotic disorder, particularly if they live in areas of ethnic segregation, or low own group ethnic density. The neurobiological mechanisms underlying this ethnic minority associated risk are unknown. We used functional...

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Autores principales: McCutcheon, Robert, Bloomfield, Michael A. P., Dahoun, Tarik, Quinlan, Marina, Terbeck, Sylvia, Mehta, Mitul, Howes, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933521/
https://www.ncbi.nlm.nih.gov/pubmed/29328019
http://dx.doi.org/10.1017/S0033291717003506
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author McCutcheon, Robert
Bloomfield, Michael A. P.
Dahoun, Tarik
Quinlan, Marina
Terbeck, Sylvia
Mehta, Mitul
Howes, Oliver
author_facet McCutcheon, Robert
Bloomfield, Michael A. P.
Dahoun, Tarik
Quinlan, Marina
Terbeck, Sylvia
Mehta, Mitul
Howes, Oliver
author_sort McCutcheon, Robert
collection PubMed
description BACKGROUND: Ethnic minority individuals have an increased risk of developing a psychotic disorder, particularly if they live in areas of ethnic segregation, or low own group ethnic density. The neurobiological mechanisms underlying this ethnic minority associated risk are unknown. We used functional MRI to investigate neural responses to faces of different ethnicity, in individuals of black ethnicity, and a control group of white British ethnicity individuals. METHODS: In total 20 individuals of black ethnicity, and 22 individuals of white British ethnicity underwent a 3T MRI scan while viewing faces of black and white ethnicity. Own group ethnic density was calculated from the 2011 census. Neighbourhood segregation was quantified using the Index of Dissimilarity method. RESULTS: At the within-group level, both groups showed greater right amygdala activation to outgroup faces. Between groups, the black ethnicity group showed greater right amygdala activation to white faces, compared to the white ethnicity group. Within the black ethnicity group, individuals living in areas of lower own group ethnic density showed greater right amygdala reactivity to white faces (r = −0.61, p = 0.01). CONCLUSIONS: This is the first time an increased amygdala response to white faces has been demonstrated in individuals of black ethnicity. In the black ethnicity group, correlations were observed between amygdala response and neighbourhood variables associated with increased psychosis risk. These results may have relevance for our understanding of the increased rates of paranoia and psychotic disorders in ethnic minority individuals.
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spelling pubmed-59335212018-09-17 Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study McCutcheon, Robert Bloomfield, Michael A. P. Dahoun, Tarik Quinlan, Marina Terbeck, Sylvia Mehta, Mitul Howes, Oliver Psychol Med Original Articles BACKGROUND: Ethnic minority individuals have an increased risk of developing a psychotic disorder, particularly if they live in areas of ethnic segregation, or low own group ethnic density. The neurobiological mechanisms underlying this ethnic minority associated risk are unknown. We used functional MRI to investigate neural responses to faces of different ethnicity, in individuals of black ethnicity, and a control group of white British ethnicity individuals. METHODS: In total 20 individuals of black ethnicity, and 22 individuals of white British ethnicity underwent a 3T MRI scan while viewing faces of black and white ethnicity. Own group ethnic density was calculated from the 2011 census. Neighbourhood segregation was quantified using the Index of Dissimilarity method. RESULTS: At the within-group level, both groups showed greater right amygdala activation to outgroup faces. Between groups, the black ethnicity group showed greater right amygdala activation to white faces, compared to the white ethnicity group. Within the black ethnicity group, individuals living in areas of lower own group ethnic density showed greater right amygdala reactivity to white faces (r = −0.61, p = 0.01). CONCLUSIONS: This is the first time an increased amygdala response to white faces has been demonstrated in individuals of black ethnicity. In the black ethnicity group, correlations were observed between amygdala response and neighbourhood variables associated with increased psychosis risk. These results may have relevance for our understanding of the increased rates of paranoia and psychotic disorders in ethnic minority individuals. Cambridge University Press 2018-09 2018-01-12 /pmc/articles/PMC5933521/ /pubmed/29328019 http://dx.doi.org/10.1017/S0033291717003506 Text en © Cambridge University Press 2018 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
McCutcheon, Robert
Bloomfield, Michael A. P.
Dahoun, Tarik
Quinlan, Marina
Terbeck, Sylvia
Mehta, Mitul
Howes, Oliver
Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study
title Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study
title_full Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study
title_fullStr Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study
title_full_unstemmed Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study
title_short Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study
title_sort amygdala reactivity in ethnic minorities and its relationship to the social environment: an fmri study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933521/
https://www.ncbi.nlm.nih.gov/pubmed/29328019
http://dx.doi.org/10.1017/S0033291717003506
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