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Multiple Myeloma with Primary Manifestation in the Mandible
Multiple myeloma (MM) is a malignant neoplasm of plasma cell origin. It usually has a multicentric origin within the bone. It contributes to about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that results...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933576/ https://www.ncbi.nlm.nih.gov/pubmed/29732272 http://dx.doi.org/10.7759/cureus.2265 |
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author | Ali, Ibrahim K Parate, Amit R Kasat, Vikrant O Dora, Amaresh |
author_facet | Ali, Ibrahim K Parate, Amit R Kasat, Vikrant O Dora, Amaresh |
author_sort | Ali, Ibrahim K |
collection | PubMed |
description | Multiple myeloma (MM) is a malignant neoplasm of plasma cell origin. It usually has a multicentric origin within the bone. It contributes to about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that results from a single malignant precursor that has undergone an uncontrolled mitotic division. Later, these cells produce one type of immunoglobulin light chain, either kappa or lambda. We present a case of a 46‑year‑old male patient who presented with a swelling of the mandible. The punched-out radiolucencies in the skull radiograph and the immunohistochemistry confirmed the case as MM. |
format | Online Article Text |
id | pubmed-5933576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-59335762018-05-04 Multiple Myeloma with Primary Manifestation in the Mandible Ali, Ibrahim K Parate, Amit R Kasat, Vikrant O Dora, Amaresh Cureus Radiology Multiple myeloma (MM) is a malignant neoplasm of plasma cell origin. It usually has a multicentric origin within the bone. It contributes to about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that results from a single malignant precursor that has undergone an uncontrolled mitotic division. Later, these cells produce one type of immunoglobulin light chain, either kappa or lambda. We present a case of a 46‑year‑old male patient who presented with a swelling of the mandible. The punched-out radiolucencies in the skull radiograph and the immunohistochemistry confirmed the case as MM. Cureus 2018-03-03 /pmc/articles/PMC5933576/ /pubmed/29732272 http://dx.doi.org/10.7759/cureus.2265 Text en Copyright © 2018, Ali et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Radiology Ali, Ibrahim K Parate, Amit R Kasat, Vikrant O Dora, Amaresh Multiple Myeloma with Primary Manifestation in the Mandible |
title | Multiple Myeloma with Primary Manifestation in the Mandible |
title_full | Multiple Myeloma with Primary Manifestation in the Mandible |
title_fullStr | Multiple Myeloma with Primary Manifestation in the Mandible |
title_full_unstemmed | Multiple Myeloma with Primary Manifestation in the Mandible |
title_short | Multiple Myeloma with Primary Manifestation in the Mandible |
title_sort | multiple myeloma with primary manifestation in the mandible |
topic | Radiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933576/ https://www.ncbi.nlm.nih.gov/pubmed/29732272 http://dx.doi.org/10.7759/cureus.2265 |
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