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Multiple Myeloma with Primary Manifestation in the Mandible

Multiple myeloma (MM) is a malignant neoplasm of plasma cell origin. It usually has a multicentric origin within the bone. It contributes to about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that results...

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Detalles Bibliográficos
Autores principales: Ali, Ibrahim K, Parate, Amit R, Kasat, Vikrant O, Dora, Amaresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933576/
https://www.ncbi.nlm.nih.gov/pubmed/29732272
http://dx.doi.org/10.7759/cureus.2265
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author Ali, Ibrahim K
Parate, Amit R
Kasat, Vikrant O
Dora, Amaresh
author_facet Ali, Ibrahim K
Parate, Amit R
Kasat, Vikrant O
Dora, Amaresh
author_sort Ali, Ibrahim K
collection PubMed
description Multiple myeloma (MM) is a malignant neoplasm of plasma cell origin. It usually has a multicentric origin within the bone. It contributes to about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that results from a single malignant precursor that has undergone an uncontrolled mitotic division. Later, these cells produce one type of immunoglobulin light chain, either kappa or lambda. We present a case of a 46‑year‑old male patient who presented with a swelling of the mandible. The punched-out radiolucencies in the skull radiograph and the immunohistochemistry confirmed the case as MM.
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spelling pubmed-59335762018-05-04 Multiple Myeloma with Primary Manifestation in the Mandible Ali, Ibrahim K Parate, Amit R Kasat, Vikrant O Dora, Amaresh Cureus Radiology Multiple myeloma (MM) is a malignant neoplasm of plasma cell origin. It usually has a multicentric origin within the bone. It contributes to about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that results from a single malignant precursor that has undergone an uncontrolled mitotic division. Later, these cells produce one type of immunoglobulin light chain, either kappa or lambda. We present a case of a 46‑year‑old male patient who presented with a swelling of the mandible. The punched-out radiolucencies in the skull radiograph and the immunohistochemistry confirmed the case as MM. Cureus 2018-03-03 /pmc/articles/PMC5933576/ /pubmed/29732272 http://dx.doi.org/10.7759/cureus.2265 Text en Copyright © 2018, Ali et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiology
Ali, Ibrahim K
Parate, Amit R
Kasat, Vikrant O
Dora, Amaresh
Multiple Myeloma with Primary Manifestation in the Mandible
title Multiple Myeloma with Primary Manifestation in the Mandible
title_full Multiple Myeloma with Primary Manifestation in the Mandible
title_fullStr Multiple Myeloma with Primary Manifestation in the Mandible
title_full_unstemmed Multiple Myeloma with Primary Manifestation in the Mandible
title_short Multiple Myeloma with Primary Manifestation in the Mandible
title_sort multiple myeloma with primary manifestation in the mandible
topic Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933576/
https://www.ncbi.nlm.nih.gov/pubmed/29732272
http://dx.doi.org/10.7759/cureus.2265
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