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Ebolaviruses: New roles for old proteins
In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied exte...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933699/ https://www.ncbi.nlm.nih.gov/pubmed/29723187 http://dx.doi.org/10.1371/journal.pntd.0006349 |
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author | Cantoni, Diego Rossman, Jeremy S. |
author_facet | Cantoni, Diego Rossman, Jeremy S. |
author_sort | Cantoni, Diego |
collection | PubMed |
description | In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied extensively since the discovery of the virus in 1976; however, the recent expansion of ebolavirus research has led to the discovery of new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenicity, whilst enhancing our understanding of the broad functions of each ebolavirus viral protein (VP). Many of these new functions appear to be unrelated to the protein’s primary function during virus replication. Such new functions range from bystander T-lymphocyte death caused by VP40-secreted exosomes to new roles for VP24 in viral particle formation. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity. |
format | Online Article Text |
id | pubmed-5933699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59336992018-05-11 Ebolaviruses: New roles for old proteins Cantoni, Diego Rossman, Jeremy S. PLoS Negl Trop Dis Review In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied extensively since the discovery of the virus in 1976; however, the recent expansion of ebolavirus research has led to the discovery of new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenicity, whilst enhancing our understanding of the broad functions of each ebolavirus viral protein (VP). Many of these new functions appear to be unrelated to the protein’s primary function during virus replication. Such new functions range from bystander T-lymphocyte death caused by VP40-secreted exosomes to new roles for VP24 in viral particle formation. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity. Public Library of Science 2018-05-03 /pmc/articles/PMC5933699/ /pubmed/29723187 http://dx.doi.org/10.1371/journal.pntd.0006349 Text en © 2018 Cantoni, Rossman http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Cantoni, Diego Rossman, Jeremy S. Ebolaviruses: New roles for old proteins |
title | Ebolaviruses: New roles for old proteins |
title_full | Ebolaviruses: New roles for old proteins |
title_fullStr | Ebolaviruses: New roles for old proteins |
title_full_unstemmed | Ebolaviruses: New roles for old proteins |
title_short | Ebolaviruses: New roles for old proteins |
title_sort | ebolaviruses: new roles for old proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933699/ https://www.ncbi.nlm.nih.gov/pubmed/29723187 http://dx.doi.org/10.1371/journal.pntd.0006349 |
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