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Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women

BACKGROUND: Pregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions...

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Autores principales: Fichman, Vivian, do Valle, Antonio Carlos Francesconi, de Macedo, Priscila Marques, Freitas, Dayvison Francis Saraiva, de Oliveira, Manoel Marques Evangelista, Almeida-Paes, Rodrigo, Gutierrez-Galhardo, Maria Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933803/
https://www.ncbi.nlm.nih.gov/pubmed/29684015
http://dx.doi.org/10.1371/journal.pntd.0006434
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author Fichman, Vivian
do Valle, Antonio Carlos Francesconi
de Macedo, Priscila Marques
Freitas, Dayvison Francis Saraiva
de Oliveira, Manoel Marques Evangelista
Almeida-Paes, Rodrigo
Gutierrez-Galhardo, Maria Clara
author_facet Fichman, Vivian
do Valle, Antonio Carlos Francesconi
de Macedo, Priscila Marques
Freitas, Dayvison Francis Saraiva
de Oliveira, Manoel Marques Evangelista
Almeida-Paes, Rodrigo
Gutierrez-Galhardo, Maria Clara
author_sort Fichman, Vivian
collection PubMed
description BACKGROUND: Pregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions, requires that the patient faithfully apply it, and it could cause skin burns. Cryosurgery is a useful therapeutic tool for many cutaneous infectious diseases, safe for pregnant women, but not well evaluated for sporotrichosis treatment in this group. METHODOLOGY: The authors conducted a retrospective study describing epidemiological, clinical, and therapeutic data related to four pregnant patients with sporotrichosis treated with cryosurgery. The authors reviewed the clinical records of four pregnant patients diagnosed with cutaneous sporotrichosis and treated with cryosurgery. The sessions were carried out monthly up to clinical cure. Molecular identification of the Sporothrix species was performed in two cases using T3B PCR fingerprinting assays. PRINCIPAL FINDINGS: All patients were in the second trimester of pregnancy and their age ranged from 18 to 34 years. With regard to clinical presentation, two patients had lymphocutaneous and two had the fixed form. S. brasiliensis was identified in two cases as the causative agent. Cryosurgery was well tolerated and the number of sessions ranged from 1 to 3. All the patients reached a complete clinical cure. CONCLUSIONS: Cryosurgery was a safe, easy to perform and well tolerated method, and therefore it is suggested to be a suitable option for the treatment of cutaneous sporotrichosis in pregnant women.
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spelling pubmed-59338032018-05-18 Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women Fichman, Vivian do Valle, Antonio Carlos Francesconi de Macedo, Priscila Marques Freitas, Dayvison Francis Saraiva de Oliveira, Manoel Marques Evangelista Almeida-Paes, Rodrigo Gutierrez-Galhardo, Maria Clara PLoS Negl Trop Dis Research Article BACKGROUND: Pregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions, requires that the patient faithfully apply it, and it could cause skin burns. Cryosurgery is a useful therapeutic tool for many cutaneous infectious diseases, safe for pregnant women, but not well evaluated for sporotrichosis treatment in this group. METHODOLOGY: The authors conducted a retrospective study describing epidemiological, clinical, and therapeutic data related to four pregnant patients with sporotrichosis treated with cryosurgery. The authors reviewed the clinical records of four pregnant patients diagnosed with cutaneous sporotrichosis and treated with cryosurgery. The sessions were carried out monthly up to clinical cure. Molecular identification of the Sporothrix species was performed in two cases using T3B PCR fingerprinting assays. PRINCIPAL FINDINGS: All patients were in the second trimester of pregnancy and their age ranged from 18 to 34 years. With regard to clinical presentation, two patients had lymphocutaneous and two had the fixed form. S. brasiliensis was identified in two cases as the causative agent. Cryosurgery was well tolerated and the number of sessions ranged from 1 to 3. All the patients reached a complete clinical cure. CONCLUSIONS: Cryosurgery was a safe, easy to perform and well tolerated method, and therefore it is suggested to be a suitable option for the treatment of cutaneous sporotrichosis in pregnant women. Public Library of Science 2018-04-23 /pmc/articles/PMC5933803/ /pubmed/29684015 http://dx.doi.org/10.1371/journal.pntd.0006434 Text en © 2018 Fichman et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fichman, Vivian
do Valle, Antonio Carlos Francesconi
de Macedo, Priscila Marques
Freitas, Dayvison Francis Saraiva
de Oliveira, Manoel Marques Evangelista
Almeida-Paes, Rodrigo
Gutierrez-Galhardo, Maria Clara
Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women
title Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women
title_full Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women
title_fullStr Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women
title_full_unstemmed Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women
title_short Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women
title_sort cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933803/
https://www.ncbi.nlm.nih.gov/pubmed/29684015
http://dx.doi.org/10.1371/journal.pntd.0006434
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