Autophagy in inflammation: the p38α MAPK-ULK1 axis

Autophagy and inflammation are two processes vital for immune cells to perform their functions. Their proper interplay upon signal is pivotal for proper response to stress. The stress kinase p38α MAPK in microglia senses inflammatory cue LPS, directly phosphorylates ULK1, relieves the autophagic inh...

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Detalles Bibliográficos
Autores principales: She, Hua, He, Yingli, Zhao, Yingren, Mao, Zixu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933864/
https://www.ncbi.nlm.nih.gov/pubmed/29732413
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author She, Hua
He, Yingli
Zhao, Yingren
Mao, Zixu
author_facet She, Hua
He, Yingli
Zhao, Yingren
Mao, Zixu
author_sort She, Hua
collection PubMed
description Autophagy and inflammation are two processes vital for immune cells to perform their functions. Their proper interplay upon signal is pivotal for proper response to stress. The stress kinase p38α MAPK in microglia senses inflammatory cue LPS, directly phosphorylates ULK1, relieves the autophagic inhibition on the inflammatory machinery, and thus allows for a full immune response.
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spelling pubmed-59338642018-05-03 Autophagy in inflammation: the p38α MAPK-ULK1 axis She, Hua He, Yingli Zhao, Yingren Mao, Zixu Macrophage (Houst) Article Autophagy and inflammation are two processes vital for immune cells to perform their functions. Their proper interplay upon signal is pivotal for proper response to stress. The stress kinase p38α MAPK in microglia senses inflammatory cue LPS, directly phosphorylates ULK1, relieves the autophagic inhibition on the inflammatory machinery, and thus allows for a full immune response. 2018-03-09 2018 /pmc/articles/PMC5933864/ /pubmed/29732413 Text en http://creativecommons.org/licenses/by/4.0/ Licensed under a Creative Commons Attribution 4.0 International License which allows users including authors of articles to copy and redistribute the material in any medium or format, in addition to remix, transform, and build upon the material for any purpose, even commercially, as long as the author and original source are properly cited or credited.
spellingShingle Article
She, Hua
He, Yingli
Zhao, Yingren
Mao, Zixu
Autophagy in inflammation: the p38α MAPK-ULK1 axis
title Autophagy in inflammation: the p38α MAPK-ULK1 axis
title_full Autophagy in inflammation: the p38α MAPK-ULK1 axis
title_fullStr Autophagy in inflammation: the p38α MAPK-ULK1 axis
title_full_unstemmed Autophagy in inflammation: the p38α MAPK-ULK1 axis
title_short Autophagy in inflammation: the p38α MAPK-ULK1 axis
title_sort autophagy in inflammation: the p38α mapk-ulk1 axis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933864/
https://www.ncbi.nlm.nih.gov/pubmed/29732413
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AT zhaoyingren autophagyininflammationthep38amapkulk1axis
AT maozixu autophagyininflammationthep38amapkulk1axis

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