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Insulin degludec in the first trimester of pregnancy: Report of two cases

Insulin degludec is an extra‐long‐acting insulin analog that allows for enhanced efficacy and flexibility in the injection time. However, it is not approved for use during pregnancy. We report the pregnancy outcome and newborn conditions in two women with type 1 diabetes who continued preconception...

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Autores principales: Milluzzo, Agostino, Tumminia, Andrea, Scalisi, Nunzio M, Frittitta, Lucia, Vigneri, Riccardo, Sciacca, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934254/
https://www.ncbi.nlm.nih.gov/pubmed/28767190
http://dx.doi.org/10.1111/jdi.12721
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author Milluzzo, Agostino
Tumminia, Andrea
Scalisi, Nunzio M
Frittitta, Lucia
Vigneri, Riccardo
Sciacca, Laura
author_facet Milluzzo, Agostino
Tumminia, Andrea
Scalisi, Nunzio M
Frittitta, Lucia
Vigneri, Riccardo
Sciacca, Laura
author_sort Milluzzo, Agostino
collection PubMed
description Insulin degludec is an extra‐long‐acting insulin analog that allows for enhanced efficacy and flexibility in the injection time. However, it is not approved for use during pregnancy. We report the pregnancy outcome and newborn conditions in two women with type 1 diabetes who continued preconception degludec treatment during embryogenesis. No pregnancy complication or congenital neonatal malformation was observed. Both babies presented with hypoglycemia and required neonatal intensive care unit admission. Degludec treatment did not cause adverse effects in the mothers or malformations in the newborns. The observed neonatal complications were probably independent of early pregnancy degludec treatment.
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spelling pubmed-59342542018-05-10 Insulin degludec in the first trimester of pregnancy: Report of two cases Milluzzo, Agostino Tumminia, Andrea Scalisi, Nunzio M Frittitta, Lucia Vigneri, Riccardo Sciacca, Laura J Diabetes Investig Articles Insulin degludec is an extra‐long‐acting insulin analog that allows for enhanced efficacy and flexibility in the injection time. However, it is not approved for use during pregnancy. We report the pregnancy outcome and newborn conditions in two women with type 1 diabetes who continued preconception degludec treatment during embryogenesis. No pregnancy complication or congenital neonatal malformation was observed. Both babies presented with hypoglycemia and required neonatal intensive care unit admission. Degludec treatment did not cause adverse effects in the mothers or malformations in the newborns. The observed neonatal complications were probably independent of early pregnancy degludec treatment. John Wiley and Sons Inc. 2017-08-30 2018-05 /pmc/articles/PMC5934254/ /pubmed/28767190 http://dx.doi.org/10.1111/jdi.12721 Text en © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Articles
Milluzzo, Agostino
Tumminia, Andrea
Scalisi, Nunzio M
Frittitta, Lucia
Vigneri, Riccardo
Sciacca, Laura
Insulin degludec in the first trimester of pregnancy: Report of two cases
title Insulin degludec in the first trimester of pregnancy: Report of two cases
title_full Insulin degludec in the first trimester of pregnancy: Report of two cases
title_fullStr Insulin degludec in the first trimester of pregnancy: Report of two cases
title_full_unstemmed Insulin degludec in the first trimester of pregnancy: Report of two cases
title_short Insulin degludec in the first trimester of pregnancy: Report of two cases
title_sort insulin degludec in the first trimester of pregnancy: report of two cases
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934254/
https://www.ncbi.nlm.nih.gov/pubmed/28767190
http://dx.doi.org/10.1111/jdi.12721
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