Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes

Most of type 2 diabetes (T2D) is thought to be the result of interaction between genetic and environmental factors. However, the genetic components discovered to date can explain only a small proportion of the observed heritability. The “missing heritability” may be accounted for by rare variants, g...

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Detalles Bibliográficos
Autor principal: Yokoi, Norihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934264/
https://www.ncbi.nlm.nih.gov/pubmed/28786564
http://dx.doi.org/10.1111/jdi.12724
Descripción
Sumario:Most of type 2 diabetes (T2D) is thought to be the result of interaction between genetic and environmental factors. However, the genetic components discovered to date can explain only a small proportion of the observed heritability. The “missing heritability” may be accounted for by rare variants, gene‐environment interactions, and epigenetics. [Image: see text]

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