Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes

Most of type 2 diabetes (T2D) is thought to be the result of interaction between genetic and environmental factors. However, the genetic components discovered to date can explain only a small proportion of the observed heritability. The “missing heritability” may be accounted for by rare variants, g...

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Detalles Bibliográficos
Autor principal: Yokoi, Norihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934264/
https://www.ncbi.nlm.nih.gov/pubmed/28786564
http://dx.doi.org/10.1111/jdi.12724
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author Yokoi, Norihide
author_facet Yokoi, Norihide
author_sort Yokoi, Norihide
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description Most of type 2 diabetes (T2D) is thought to be the result of interaction between genetic and environmental factors. However, the genetic components discovered to date can explain only a small proportion of the observed heritability. The “missing heritability” may be accounted for by rare variants, gene‐environment interactions, and epigenetics. [Image: see text]
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spelling pubmed-59342642018-05-10 Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes Yokoi, Norihide J Diabetes Investig Commentaries Most of type 2 diabetes (T2D) is thought to be the result of interaction between genetic and environmental factors. However, the genetic components discovered to date can explain only a small proportion of the observed heritability. The “missing heritability” may be accounted for by rare variants, gene‐environment interactions, and epigenetics. [Image: see text] John Wiley and Sons Inc. 2017-10-03 2018-05 /pmc/articles/PMC5934264/ /pubmed/28786564 http://dx.doi.org/10.1111/jdi.12724 Text en © 2017 The Author. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentaries
Yokoi, Norihide
Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
title Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
title_full Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
title_fullStr Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
title_full_unstemmed Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
title_short Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
title_sort epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934264/
https://www.ncbi.nlm.nih.gov/pubmed/28786564
http://dx.doi.org/10.1111/jdi.12724
work_keys_str_mv AT yokoinorihide epigeneticdysregulationinpancreaticisletsandpathogenesisoftype2diabetes

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