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Case of lipoatrophic diabetes induced by juvenile dermatomyositis

Lipodystrophy is a rare condition that is often accompanied by one or more metabolic diseases. Here, we report a case of lipoatrophic diabetes induced by juvenile dermatomyositis. Although pioglitazone was not effective for lowering blood glucose levels, our observation suggested that it improved li...

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Detalles Bibliográficos
Autores principales: Baba, Yusuke, Kaneko, Hiyori, Takemoto, Minoru, Ide, Kana, Haga, Yuki, Kanda, Tatsuo, Akita, Shinsuke, Kubota, Yoshitaka, Kuroda, Masayuki, Kitagawa, Yutaka, Yokote, Koutaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934268/
https://www.ncbi.nlm.nih.gov/pubmed/28895299
http://dx.doi.org/10.1111/jdi.12745
Descripción
Sumario:Lipodystrophy is a rare condition that is often accompanied by one or more metabolic diseases. Here, we report a case of lipoatrophic diabetes induced by juvenile dermatomyositis. Although pioglitazone was not effective for lowering blood glucose levels, our observation suggested that it improved liver function slightly. The effectiveness of metreleptin for lowering blood glucose levels could not be determined, as we administered it in a short period. Liver biopsy showed burned‐out non‐alcoholic steatohepatitis. The present results show that the successful treatment of lipoatrophic diabetes induced by juvenile dermatomyositis requires an early diagnosis and therapeutic intervention.