Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Plants containing aristolochic acids (AA) are nephrotoxins. Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism. This study aims to determine the role of GNMT in AA-induced nephropathy. W...

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Detalles Bibliográficos
Autores principales: Chang, Ming-Min, Lin, Chang-Ni, Fang, Cheng-Chieh, Chen, Marcelo, Liang, Peir-In, Li, Wei-Ming, Yeh, Bi-Wen, Cheng, Hung-Chi, Huang, Bu-Miin, Wu, Wen-Jeng, Chen, Yi-Ming Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934382/
https://www.ncbi.nlm.nih.gov/pubmed/29725048
http://dx.doi.org/10.1038/s41598-018-22298-6

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