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The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming

Human PrimPol is a monomeric enzyme whose DNA primase activity is required to rescue stalled replication forks during nuclear and mitochondrial DNA replication. PrimPol contains an Archeal-Eukaryotic Primases (AEP) core followed by a C-terminal Zn finger-containing domain (ZnFD), that is exclusively...

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Detalles Bibliográficos
Autores principales:	Martínez-Jiménez, María I, Calvo, Patricia A, García-Gómez, Sara, Guerra-González, Susana, Blanco, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934617/ https://www.ncbi.nlm.nih.gov/pubmed/29608762 http://dx.doi.org/10.1093/nar/gky230

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