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Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus

CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that targeted disruption of the CHD1 gene in human cells leads to a defect in early double-strand break (DSB) repair via h...

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Detalles Bibliográficos
Autores principales:	Zhou, Jia, Li, Jiaqi, Serafim, Rodolfo B, Ketchum, Steven, Ferreira, Catarina G, Liu, Jessica C, Coe, Kathryn A, Price, Brendan D, Yusufzai, Timur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934646/ https://www.ncbi.nlm.nih.gov/pubmed/29529298 http://dx.doi.org/10.1093/nar/gky128

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