A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance

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Imidazopyrazinones (IPYs) are a new class of compounds that target bacterial topoisomerases as a basis for their antibacterial activity. We have characterized the mechanism of these compounds through structural/mechanistic studies showing they bind and stabilize a cleavage complex between DNA gyrase...

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Detalles Bibliográficos
Autores principales: Germe, Thomas, Vörös, Judit, Jeannot, Frederic, Taillier, Thomas, Stavenger, Robert A, Bacqué, Eric, Maxwell, Anthony, Bax, Benjamin D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934680/
https://www.ncbi.nlm.nih.gov/pubmed/29538767
http://dx.doi.org/10.1093/nar/gky181

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