A multi-landing pad DNA integration platform for mammalian cell engineering

Engineering mammalian cell lines that stably express many transgenes requires the precise insertion of large amounts of heterologous DNA into well-characterized genomic loci, but current methods are limited. To facilitate reliable large-scale engineering of CHO cells, we identified 21 novel genomic...

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Detalles Bibliográficos
Autores principales: Gaidukov, Leonid, Wroblewska, Liliana, Teague, Brian, Nelson, Tom, Zhang, Xin, Liu, Yan, Jagtap, Kalpana, Mamo, Selamawit, Tseng, Wen Allen, Lowe, Alexis, Das, Jishnu, Bandara, Kalpanie, Baijuraj, Swetha, Summers, Nevin M, Lu, Timothy K, Zhang, Lin, Weiss, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934685/
https://www.ncbi.nlm.nih.gov/pubmed/29617873
http://dx.doi.org/10.1093/nar/gky216

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