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Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb

This study was undertaken to examine the antinociceptive, antihyperglycemic, and membrane stabilizing activity with phytochemical screening of methanolic extract of Garcinia lanceifolia whole plant. The extracts were subjected to in-vivo antinociceptive, antihyperglycemic activity in laboratory anim...

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Detalles Bibliográficos
Autores principales: Ghosh, Antara, Banik, Sujan, Amin, Mohammad Nurul, Ahmed, Jamiuddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934706/
https://www.ncbi.nlm.nih.gov/pubmed/29736386
http://dx.doi.org/10.1016/j.jtcme.2017.04.009
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author Ghosh, Antara
Banik, Sujan
Amin, Mohammad Nurul
Ahmed, Jamiuddin
author_facet Ghosh, Antara
Banik, Sujan
Amin, Mohammad Nurul
Ahmed, Jamiuddin
author_sort Ghosh, Antara
collection PubMed
description This study was undertaken to examine the antinociceptive, antihyperglycemic, and membrane stabilizing activity with phytochemical screening of methanolic extract of Garcinia lanceifolia whole plant. The extracts were subjected to in-vivo antinociceptive, antihyperglycemic activity in laboratory animals and in-vitro membrane stabilizing activity. In peripheral antinociceptive activity, G. lanceifolia (400 and 200 mg/kg) exhibited significant (P < 0.001) inhibition of writhing with 59.15% and 49.30% respectively comparable to standard Diclofenac (54.92% inhibition). In central antinociceptive activity, the extract (400 and 200 mg/kg) exhibited significant analgesic activity having 78.31% (P < 0.05) and 89.95% (P < 0.01) elongation of reaction time respectively in 90 min after administration of sample comparable to the standard Morphine (708.99% elongation). In hypoglycemic activity, the extract (400 and 200 mg/kg) exhibit statistically significant (P < 0.001) antihyperglycemic activity compared to standard drug Glibenclamide (10 mg/kg) at different time interval. In membrane stabilizing activity assay, clearly evident that the methanolic extracts of G. lanceifolia were highly effective to prevent the lyses of erythrocytes induced by heat. The outcomes of the present study revealed that this plant possess noteworthy pharmacological activities that may be basis for further research to disclose feasible mode of action of the plant part.
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spelling pubmed-59347062018-05-07 Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb Ghosh, Antara Banik, Sujan Amin, Mohammad Nurul Ahmed, Jamiuddin J Tradit Complement Med Original Article This study was undertaken to examine the antinociceptive, antihyperglycemic, and membrane stabilizing activity with phytochemical screening of methanolic extract of Garcinia lanceifolia whole plant. The extracts were subjected to in-vivo antinociceptive, antihyperglycemic activity in laboratory animals and in-vitro membrane stabilizing activity. In peripheral antinociceptive activity, G. lanceifolia (400 and 200 mg/kg) exhibited significant (P < 0.001) inhibition of writhing with 59.15% and 49.30% respectively comparable to standard Diclofenac (54.92% inhibition). In central antinociceptive activity, the extract (400 and 200 mg/kg) exhibited significant analgesic activity having 78.31% (P < 0.05) and 89.95% (P < 0.01) elongation of reaction time respectively in 90 min after administration of sample comparable to the standard Morphine (708.99% elongation). In hypoglycemic activity, the extract (400 and 200 mg/kg) exhibit statistically significant (P < 0.001) antihyperglycemic activity compared to standard drug Glibenclamide (10 mg/kg) at different time interval. In membrane stabilizing activity assay, clearly evident that the methanolic extracts of G. lanceifolia were highly effective to prevent the lyses of erythrocytes induced by heat. The outcomes of the present study revealed that this plant possess noteworthy pharmacological activities that may be basis for further research to disclose feasible mode of action of the plant part. Elsevier 2017-05-17 /pmc/articles/PMC5934706/ /pubmed/29736386 http://dx.doi.org/10.1016/j.jtcme.2017.04.009 Text en © 2018 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ghosh, Antara
Banik, Sujan
Amin, Mohammad Nurul
Ahmed, Jamiuddin
Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb
title Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb
title_full Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb
title_fullStr Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb
title_full_unstemmed Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb
title_short Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb
title_sort evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of garcinia lancifolia roxb
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934706/
https://www.ncbi.nlm.nih.gov/pubmed/29736386
http://dx.doi.org/10.1016/j.jtcme.2017.04.009
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