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Novel degradation products of argatroban: Isolation, synthesis and extensive characterization using NMR and LC-PDA-MS/Q-TOF

Forced degradation study of argatroban under conditions of hydrolysis (neutral, acidic and alkaline), oxidation, photolysis and thermal stress, as suggested in the ICH Q1A (R2), was accomplished. The drug showed significant degradation under hydrolysis (acidic, alkaline) and oxidation (peroxide stre...

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Detalles Bibliográficos
Autores principales:	Guvvala, Vinodh, Chidambaram Subramanian, Venkatesan, Anireddy, Jaya Shree, Konda, Mahesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2018
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934711/ https://www.ncbi.nlm.nih.gov/pubmed/29736294 http://dx.doi.org/10.1016/j.jpha.2017.07.001

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