Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation

Aggregation of α‐synuclein is a hallmark of Parkinson's disease and dementia with Lewy bodies. We here investigate the relationship between cytosolic Ca(2+) and α‐synuclein aggregation. Analyses of cell lines and primary culture models of α‐synuclein cytopathology reveal an early phase with red...

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Detalles Bibliográficos
Autores principales: Betzer, Cristine, Lassen, Louise Berkhoudt, Olsen, Anders, Kofoed, Rikke Hahn, Reimer, Lasse, Gregersen, Emil, Zheng, Jin, Calì, Tito, Gai, Wei‐Ping, Chen, Tong, Moeller, Arne, Brini, Marisa, Fu, Yuhong, Halliday, Glenda, Brudek, Tomasz, Aznar, Susana, Pakkenberg, Bente, Andersen, Jens Peter, Jensen, Poul Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934765/
https://www.ncbi.nlm.nih.gov/pubmed/29599149
http://dx.doi.org/10.15252/embr.201744617

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