Cargando…

The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity: a multicenter randomized, double-blind, clinical trial (the SPIREN trial)

BACKGROUND: Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple organs. Animal studies have indicated a beneficial effect of mineralocorticoid r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mortensen, Line Aas, Thiesson, Helle C., Tougaard, Birgitte, Egfjord, Martin, Fischer, Anne Sophie Lind, Bistrup, Claus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934785/ https://www.ncbi.nlm.nih.gov/pubmed/29724188 http://dx.doi.org/10.1186/s12882-018-0885-6

Ejemplares similares

Does Mineralocorticoid Receptor Antagonism Prevent Calcineurin Inhibitor-Induced Nephrotoxicity?
por: Mortensen, Line Aas, et al.
Publicado: (2017)

Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis—A Study in Renal Transplant Patients
por: Mortensen, Line Aas, et al.
Publicado: (2020)

The over-exaggerated chronic nephrotoxicity of calcineurin inhibitors
por: Issa, Naim, et al.
Publicado: (2012)

Spironolactone Inhibits Cardiomyocyte Hypertrophy by Regulating the Ca(2+)/Calcineurin/p-NFATc3 Pathway
por: Wang, Xin, et al.
Publicado: (2021)

Calcineurin inhibitor induced nephrotoxicity in steroid resistant nephrotic syndrome
por: Sinha, A., et al.
Publicado: (2013)

Nephrotoxicity of Calcineurin Inhibitors in Kidney Epithelial Cells is Independent of NFAT Signaling
por: Karolin, Andrea, et al.
Publicado: (2022)

Amiloride resolves resistant edema and hypertension in a patient with nephrotic syndrome; a case report
por: Hinrichs, Gitte R., et al.
Publicado: (2018)

Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity
por: Gooch, Jennifer L., et al.
Publicado: (2017)

Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model
por: Ali, Ahmed Shaker, et al.
Publicado: (2020)

Association of high intra-patient variability in tacrolimus exposure with calcineurin inhibitor nephrotoxicity in kidney transplantation
por: Kim, Hyokee, et al.
Publicado: (2023)

Effect of Spironolactone on Diabetic Nephropathy Compared to the Combination of Spironolactone and Losartan
por: Makhlough, Atieh, et al.
Publicado: (2014)

Spironolactone in Atrial Fibrillation With Preserved Cardiac Fraction: The IMPRESS‐AF Trial
por: Shantsila, Eduard, et al.
Publicado: (2020)

FASCE, the benefit of spironolactone for treating acne in women: study protocol for a randomized double-blind trial
por: Poinas, Alexandra, et al.
Publicado: (2020)

Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis
por: Xia, Tianyi, et al.
Publicado: (2018)

An Integrated Transcriptomic Approach to Identify Molecular Markers of Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients
por: Rhone, Erika T., et al.
Publicado: (2021)

Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model [Corrigendum]
Publicado: (2023)

Effect of Spironolactone in Resistant Arterial Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial (ASPIRANT-EXT)
por: Václavík, Jan, et al.
Publicado: (2014)

Effect of spironolactone on vascular stiffness in hemodialysis patients: a randomized crossover trial
por: Eklund, Michael, et al.
Publicado: (2022)

Treatment of Nephrogenic Diabetes Insipidus Patients With cGMP-Stimulating Drugs Does Not Mitigate Polyuria or Increase Urinary Concentrating Ability
por: Hinrichs, Gitte R., et al.
Publicado: (2020)

A Low Tacrolimus Concentration/Dose Ratio Increases the Risk for the Development of Acute Calcineurin Inhibitor-Induced Nephrotoxicity
por: Thölking, Gerold, et al.
Publicado: (2019)

The Calcineurin Inhibitor-Sparing (CIS) Trial - individualised calcineurin-inhibitor treatment by immunomonitoring in renal allograft recipients: protocol for a randomised controlled trial
por: Sommerer, Claudia, et al.
Publicado: (2014)

Effect of spironolactone use in pulmonary arterial hypertension – analysis from pivotal trial databases
por: Safdar, Zeenat, et al.
Publicado: (2021)

A Randomized Trial of Sitagliptin and Spironolactone With Combination Therapy in Hospitalized Adults With COVID-19
por: Abbasi, Farhad, et al.
Publicado: (2022)

Safety and Efficacy of Spironolactone in Dialysis-Dependent Patients: Meta-Analysis of Randomized Controlled Trials
por: Liu, Jing, et al.
Publicado: (2022)

A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial
por: Hayer, Manvir K., et al.
Publicado: (2017)

THU340 Efficacy And Safety Of Low-dose Spironolactone On Chronic Kidney Disease In Adults With Type 2 Diabetes: A Multicenter, Randomized Clinical Trial
por: Oiwa, Ako, et al.
Publicado: (2023)

Renal histopathological lesions after liver transplantation: What can we find besides calcineurin inhibitor-induced nephrotoxicity?
por: Jin, Haijiao, et al.
Publicado: (2022)

Spironolactone-Induced Unilateral Gynecomastia
por: Veeregowda, Sahana Hadihalli, et al.
Publicado: (2018)

Zinc oxide nanoparticles and spironolactone-enhanced Nrf2/HO-1 pathway and inhibited Wnt/β-catenin pathway in adenine-induced nephrotoxicity in rats
por: Awadalla, Amira, et al.
Publicado: (2022)

Efficacy of Spironolactone as an Adjunctive Therapy to Risperidone to Improve Symptoms of Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial
por: Zandifar, Atefeh, et al.
Publicado: (2022)

Effects of spironolactone on extrasystoles and heart rate variability in haemodialysis patients: a randomised crossover trial
por: Eklund, Michael, et al.
Publicado: (2021)

Effects of Spironolactone on Arrhythmias in Hemodialysis Patients: Secondary Results of the SPin-D Randomized Controlled Trial
por: Mc Causland, Finnian R., et al.
Publicado: (2023)

Add-on spironolactone as antagonist of the NRG1-ERBB4 signaling pathway for the treatment of schizophrenia: Study design and methodology of a multicenter randomized, placebo-controlled trial
por: Hasan, Alkomiet, et al.
Publicado: (2020)

Effectiveness of spironolactone for women with acne vulgaris (SAFA) in England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial
por: Santer, Miriam, et al.
Publicado: (2023)

Calcineurin
por: Creamer, Trevor P.
Publicado: (2020)

Colistin Nephrotoxicity: Meta-Analysis of Randomized Controlled Trials
por: Eljaaly, Khalid, et al.
Publicado: (2021)

Effect of spironolactone on pain responses in mice
por: Abdel-Salam, Omar M.E., et al.
Publicado: (2010)

Spironolactone in cardiovascular disease: an expanding universe?
por: Funder, John W.
Publicado: (2017)

Imatinib and spironolactone suppress hepcidin expression
por: Mleczko-Sanecka, Katarzyna, et al.
Publicado: (2017)

Furosemide/spironolactone: Hypotension: case report
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mvgvlkvn3q864h7naet1tb1uvv