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Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

Multidrug binding and transport by the ATP-binding cassette transporter ABCG2 is a factor in the clinical resistance to chemotherapy in leukaemia, and a contributory factor to the pharmacokinetic profiles of many other prescribed drugs. Despite its importance, the structural basis of multidrug trans...

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Detalles Bibliográficos
Autores principales:	Cox, Megan H., Kapoor, Parth, Briggs, Deborah A., Kerr, Ian D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934980/ https://www.ncbi.nlm.nih.gov/pubmed/29661915 http://dx.doi.org/10.1042/BCJ20170923

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