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Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism

PTEN-induced putative kinase 1 (PINK1) is a mitochondria-targeted kinase whose mutations are a cause of Parkinson’s disease. We set out to better understand PINK1’s effects on mitochondrial proteins in vivo. Using an unbiased phosphoproteomic screen in Drosophila, we found that PINK1 mediates the ph...

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Detalles Bibliográficos
Autores principales:	Course, Meredith M., Scott, Anna I., Schoor, Carmen, Hsieh, Chung-Han, Papakyrikos, Amanda M., Winter, Dominic, Cowan, Tina M., Wang, Xinnan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935071/ https://www.ncbi.nlm.nih.gov/pubmed/29563254 http://dx.doi.org/10.1091/mbc.E18-03-0155

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