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A Phase Ib study of ruxolitinib + gemcitabine ± nab-paclitaxel in patients with advanced solid tumors

PURPOSE: Aberrant activation of the Janus-associated kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is associated with increased malignant cell proliferation and survival. This Phase Ib study evaluated ruxolitinib, a potent JAK1/2 inhibitor, in combination with gemcitab...

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Detalles Bibliográficos
Autores principales:	Bauer, Todd M, Patel, Manish R, Forero-Torres, Andres, George, Thomas J, Assad, Albert, Du, Yining, Hurwitz, Herbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Clinical Trial Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935192/ https://www.ncbi.nlm.nih.gov/pubmed/29750040 http://dx.doi.org/10.2147/OTT.S157331

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