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Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability
Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of European descent. We identified 123 autosomal and one X-chromosome loci...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935237/ https://www.ncbi.nlm.nih.gov/pubmed/29662168 http://dx.doi.org/10.1038/s41588-018-0100-5 |
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| author | Hysi, Pirro G. Valdes, Ana Liu, Fan Furlotte, Nicholas A. Evans, David M. Bataille, Veronique Visconti, Alessia Hemani, Gibran McMahon, George Ring, Susan M. Davey Smith, George Duffy, David L. Zhu, Gu Gordon, Scott D. Medland, Sarah E. Lin, Bochao D. Willemsen, Gonneke Hottenga, JoukeJan Vuckovic, Dragana Girotto, Giorgia Gandin, Ilaria Sala, Cinzia Concas, Maria Pina Brumat, Marco Gasparini, Paolo Toniolo, Daniela Cocca, Massimiliano Robino, Antonietta Yazar, Seyhan Hewitt, Alex W. Chen, Yan Zeng, Changqing Uitterlinden, Andre G. Ikram, M. Arfan Hamer, Merel A. van Duijn, Cornelia M. Nijsten, Tamar Mackey, David A. Falchi, Mario Boomsma, Dorret I. Martin, Nicholas G. Hinds, David A. Kayser, Manfred Spector, Timothy D. |
| author_facet | Hysi, Pirro G. Valdes, Ana Liu, Fan Furlotte, Nicholas A. Evans, David M. Bataille, Veronique Visconti, Alessia Hemani, Gibran McMahon, George Ring, Susan M. Davey Smith, George Duffy, David L. Zhu, Gu Gordon, Scott D. Medland, Sarah E. Lin, Bochao D. Willemsen, Gonneke Hottenga, JoukeJan Vuckovic, Dragana Girotto, Giorgia Gandin, Ilaria Sala, Cinzia Concas, Maria Pina Brumat, Marco Gasparini, Paolo Toniolo, Daniela Cocca, Massimiliano Robino, Antonietta Yazar, Seyhan Hewitt, Alex W. Chen, Yan Zeng, Changqing Uitterlinden, Andre G. Ikram, M. Arfan Hamer, Merel A. van Duijn, Cornelia M. Nijsten, Tamar Mackey, David A. Falchi, Mario Boomsma, Dorret I. Martin, Nicholas G. Hinds, David A. Kayser, Manfred Spector, Timothy D. |
| author_sort | Hysi, Pirro G. |
| collection | PubMed |
| description | Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of European descent. We identified 123 autosomal and one X-chromosome loci significantly associated with hair color; all but 13 are novel. Collectively, SNPs associated with hair color within these loci explain 34.6% of red hair, 24.8% of blond hair and 26.1% of black hair heritability in the study populations. These results confirm the polygenic nature of complex phenotypes and improve our understanding of melanin pigment metabolism in humans. |
| format | Online Article Text |
| id | pubmed-5935237 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59352372018-10-16 Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability Hysi, Pirro G. Valdes, Ana Liu, Fan Furlotte, Nicholas A. Evans, David M. Bataille, Veronique Visconti, Alessia Hemani, Gibran McMahon, George Ring, Susan M. Davey Smith, George Duffy, David L. Zhu, Gu Gordon, Scott D. Medland, Sarah E. Lin, Bochao D. Willemsen, Gonneke Hottenga, JoukeJan Vuckovic, Dragana Girotto, Giorgia Gandin, Ilaria Sala, Cinzia Concas, Maria Pina Brumat, Marco Gasparini, Paolo Toniolo, Daniela Cocca, Massimiliano Robino, Antonietta Yazar, Seyhan Hewitt, Alex W. Chen, Yan Zeng, Changqing Uitterlinden, Andre G. Ikram, M. Arfan Hamer, Merel A. van Duijn, Cornelia M. Nijsten, Tamar Mackey, David A. Falchi, Mario Boomsma, Dorret I. Martin, Nicholas G. Hinds, David A. Kayser, Manfred Spector, Timothy D. Nat Genet Article Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of European descent. We identified 123 autosomal and one X-chromosome loci significantly associated with hair color; all but 13 are novel. Collectively, SNPs associated with hair color within these loci explain 34.6% of red hair, 24.8% of blond hair and 26.1% of black hair heritability in the study populations. These results confirm the polygenic nature of complex phenotypes and improve our understanding of melanin pigment metabolism in humans. 2018-04-16 2018-05 /pmc/articles/PMC5935237/ /pubmed/29662168 http://dx.doi.org/10.1038/s41588-018-0100-5 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Hysi, Pirro G. Valdes, Ana Liu, Fan Furlotte, Nicholas A. Evans, David M. Bataille, Veronique Visconti, Alessia Hemani, Gibran McMahon, George Ring, Susan M. Davey Smith, George Duffy, David L. Zhu, Gu Gordon, Scott D. Medland, Sarah E. Lin, Bochao D. Willemsen, Gonneke Hottenga, JoukeJan Vuckovic, Dragana Girotto, Giorgia Gandin, Ilaria Sala, Cinzia Concas, Maria Pina Brumat, Marco Gasparini, Paolo Toniolo, Daniela Cocca, Massimiliano Robino, Antonietta Yazar, Seyhan Hewitt, Alex W. Chen, Yan Zeng, Changqing Uitterlinden, Andre G. Ikram, M. Arfan Hamer, Merel A. van Duijn, Cornelia M. Nijsten, Tamar Mackey, David A. Falchi, Mario Boomsma, Dorret I. Martin, Nicholas G. Hinds, David A. Kayser, Manfred Spector, Timothy D. Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability |
| title | Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability |
| title_full | Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability |
| title_fullStr | Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability |
| title_full_unstemmed | Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability |
| title_short | Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability |
| title_sort | genome-wide association meta-analysis of individuals of european ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935237/ https://www.ncbi.nlm.nih.gov/pubmed/29662168 http://dx.doi.org/10.1038/s41588-018-0100-5 |
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