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Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1

TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of neurons and glial cells. Defects in nucleocyt...

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Detalles Bibliográficos
Autores principales:	Ederle, Helena, Funk, Christina, Abou-Ajram, Claudia, Hutten, Saskia, Funk, Eva B. E., Kehlenbach, Ralph H., Bailer, Susanne M., Dormann, Dorothee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935713/ https://www.ncbi.nlm.nih.gov/pubmed/29728564 http://dx.doi.org/10.1038/s41598-018-25007-5

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