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Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes

Oncogenic membrane receptor tyrosine kinases such as MET and EGFR, or auto-active variants thereof, are important targets for cancer precision therapy. Targeted inhibition of these oncogenic receptors however invariably leads to resistance, resulting from acquisition of resistance-inducing mutations...

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Detalles Bibliográficos
Autores principales:	van den Heuvel, Corina N. A. M., Das, Arvid I., de Bitter, Tessa, Simmer, Femke, Wurdinger, Thomas, Molina-Vila, Miguel Angel, Leenders, William P. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935718/ https://www.ncbi.nlm.nih.gov/pubmed/29728634 http://dx.doi.org/10.1038/s41598-018-25328-5

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