Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

The epigenetic mechanisms regulating adipose tissue development and function are poorly understood. In this study, we show that depletion of histone H3K36 methylation by H3.3K36M in preadipocytes inhibits adipogenesis by increasing H3K27me3 to prevent the induction of C/EBPα and other targets of the...

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Detalles Bibliográficos
Autores principales: Zhuang, Lenan, Jang, Younghoon, Park, Young-Kwon, Lee, Ji-Eun, Jain, Shalini, Froimchuk, Eugene, Broun, Aaron, Liu, Chengyu, Gavrilova, Oksana, Ge, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935725/
https://www.ncbi.nlm.nih.gov/pubmed/29728617
http://dx.doi.org/10.1038/s41467-018-04127-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935725/
https://www.ncbi.nlm.nih.gov/pubmed/29728617
http://dx.doi.org/10.1038/s41467-018-04127-6

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