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Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
The epigenetic mechanisms regulating adipose tissue development and function are poorly understood. In this study, we show that depletion of histone H3K36 methylation by H3.3K36M in preadipocytes inhibits adipogenesis by increasing H3K27me3 to prevent the induction of C/EBPα and other targets of the...
Autores principales: | Zhuang, Lenan, Jang, Younghoon, Park, Young-Kwon, Lee, Ji-Eun, Jain, Shalini, Froimchuk, Eugene, Broun, Aaron, Liu, Chengyu, Gavrilova, Oksana, Ge, Kai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935725/ https://www.ncbi.nlm.nih.gov/pubmed/29728617 http://dx.doi.org/10.1038/s41467-018-04127-6 |
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