Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells leading to intracellular drug release. Typically, only a subset of patients with solid tumours has sufficient expression of such a receptor, while there are suitable non-internalising receptors and stroma targets....

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Detalles Bibliográficos
Autores principales: Rossin, Raffaella, Versteegen, Ron M., Wu, Jeremy, Khasanov, Alisher, Wessels, Hans J., Steenbergen, Erik J., ten Hoeve, Wolter, Janssen, Henk M., van Onzen, Arthur H. A. M., Hudson, Peter J., Robillard, Marc S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935733/
https://www.ncbi.nlm.nih.gov/pubmed/29728559
http://dx.doi.org/10.1038/s41467-018-03880-y

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