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In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model

The urokinase-type plasminogen activator (uPA) loaded hollow nanogels (nUK) were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly (ethylene oxide). The resultant formulation is sensitive to diagnostic ultrasound (US) of 2 MHz. Herein, we evaluated the in vivo sonothromb...

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Detalles Bibliográficos
Autores principales:	Teng, Yuming, Jin, Haiqiang, Nan, Ding, Li, Mengnan, Fan, Chenghe, Liu, Yuanyuan, Lv, Pu, Cui, Wei, Sun, Yongan, Hao, Hongjun, Qu, Xiaozhong, Yang, Zhenzhong, Huang, Yining
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	KeAi Publishing 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935765/ https://www.ncbi.nlm.nih.gov/pubmed/29744447 http://dx.doi.org/10.1016/j.bioactmat.2017.08.001

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