Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation

BACKGROUND: Higher matrix stiffness affects biological behavior of tumor cells, regulates tumor-associated gene/miRNA expression and stemness characteristic, and contributes to tumor invasion and metastasis. However, the linkage between higher matrix stiffness and pre-metastatic niche in hepatocellu...

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Detalles Bibliográficos
Autores principales: Wu, Sifan, Zheng, Qiongdan, Xing, Xiaoxia, Dong, Yinying, Wang, Yaohui, You, Yang, Chen, Rongxin, Hu, Chao, Chen, Jie, Gao, Dongmei, Zhao, Yan, Wang, Zhiming, Xue, Tongchun, Ren, Zhenggang, Cui, Jiefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935912/
https://www.ncbi.nlm.nih.gov/pubmed/29728125
http://dx.doi.org/10.1186/s13046-018-0761-z

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