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Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat

The effect of 3- or 6-Gray (Gy) whole-body gamma irradiation on basal and stimulated gastric acid secretion was studied in pylorus-ligated rats. Different groups of rats were irradiated with a single 3- or 6-Gy fraction and examined 7 days after irradiation. Exposure to 3-Gy fraction led to marked i...

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Autores principales: Salam, Omar M. E. Abdel, Hadajat, Ihsan, Bayomy, Ayman Ragab, El-Shinawy, Siham, Arbid, Mahmoud S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936557/
https://www.ncbi.nlm.nih.gov/pubmed/15798879
http://dx.doi.org/10.1100/tsw.2005.25
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author Salam, Omar M. E. Abdel
Hadajat, Ihsan
Bayomy, Ayman Ragab
El-Shinawy, Siham
Arbid, Mahmoud S.
author_facet Salam, Omar M. E. Abdel
Hadajat, Ihsan
Bayomy, Ayman Ragab
El-Shinawy, Siham
Arbid, Mahmoud S.
author_sort Salam, Omar M. E. Abdel
collection PubMed
description The effect of 3- or 6-Gray (Gy) whole-body gamma irradiation on basal and stimulated gastric acid secretion was studied in pylorus-ligated rats. Different groups of rats were irradiated with a single 3- or 6-Gy fraction and examined 7 days after irradiation. Exposure to 3-Gy fraction led to marked increase in basal (nonstimulated) gastric acid output in the 4-h pylorus-ligated rat (47.5% compared with unirradiated controls). After exposure to 6 Gy, only 18.2% increase in gastric acid output was noted compared with unirradiated controls. Under pentagastrin or histamine stimulation, gastric acid secretion in those irradiated with 3- or 6-Gy fraction was markedly reduced compared to that of unirradiated controls. Exposure to 3- or 6-Gy gamma irradiation intensified the degree of gastric mucosal injury evoked by indomethacin or 50% ethanol in a dose-dependent manner. It is concluded that in the pylorus-ligated rat model, lower doses of gamma irradiation increase basal gastric acid secretion and impair the gastric mucosal barrier with marked increase in its permeability to H(+) following stimulation of acid secretion or exposure to barrier breakers. Exposure to irradiation is likely to result in failure of the parietal cell to respond to direct stimulation with histamine or pentagastrin.
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spelling pubmed-59365572018-06-03 Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat Salam, Omar M. E. Abdel Hadajat, Ihsan Bayomy, Ayman Ragab El-Shinawy, Siham Arbid, Mahmoud S. ScientificWorldJournal Research Article The effect of 3- or 6-Gray (Gy) whole-body gamma irradiation on basal and stimulated gastric acid secretion was studied in pylorus-ligated rats. Different groups of rats were irradiated with a single 3- or 6-Gy fraction and examined 7 days after irradiation. Exposure to 3-Gy fraction led to marked increase in basal (nonstimulated) gastric acid output in the 4-h pylorus-ligated rat (47.5% compared with unirradiated controls). After exposure to 6 Gy, only 18.2% increase in gastric acid output was noted compared with unirradiated controls. Under pentagastrin or histamine stimulation, gastric acid secretion in those irradiated with 3- or 6-Gy fraction was markedly reduced compared to that of unirradiated controls. Exposure to 3- or 6-Gy gamma irradiation intensified the degree of gastric mucosal injury evoked by indomethacin or 50% ethanol in a dose-dependent manner. It is concluded that in the pylorus-ligated rat model, lower doses of gamma irradiation increase basal gastric acid secretion and impair the gastric mucosal barrier with marked increase in its permeability to H(+) following stimulation of acid secretion or exposure to barrier breakers. Exposure to irradiation is likely to result in failure of the parietal cell to respond to direct stimulation with histamine or pentagastrin. TheScientificWorldJOURNAL 2005-03-18 /pmc/articles/PMC5936557/ /pubmed/15798879 http://dx.doi.org/10.1100/tsw.2005.25 Text en Copyright © 2005 Omar M.E. Abdel Salam et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Salam, Omar M. E. Abdel
Hadajat, Ihsan
Bayomy, Ayman Ragab
El-Shinawy, Siham
Arbid, Mahmoud S.
Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat
title Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat
title_full Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat
title_fullStr Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat
title_full_unstemmed Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat
title_short Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat
title_sort acute effect of gamma irradiation on gastric acid secretion and gastric mucosal integrity in the rat
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936557/
https://www.ncbi.nlm.nih.gov/pubmed/15798879
http://dx.doi.org/10.1100/tsw.2005.25
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