Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multip...

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Detalles Bibliográficos
Autores principales: Fusco, Dahlene N., Ganova-Raeva, Lilia, Khudyakov, Yury, Punkova, Lili, Mohamed, Aisha, Cheon, Scarlett Se Yun, Koirala, Prapti, Andersson, Karin L., Jourdain, Gonzague, Sureau, Camille, Chung, Raymond T., Lauer, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936758/
https://www.ncbi.nlm.nih.gov/pubmed/29761102
http://dx.doi.org/10.3389/fmed.2018.00097
Descripción
Sumario:A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy.

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