Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multip...

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Autores principales: Fusco, Dahlene N., Ganova-Raeva, Lilia, Khudyakov, Yury, Punkova, Lili, Mohamed, Aisha, Cheon, Scarlett Se Yun, Koirala, Prapti, Andersson, Karin L., Jourdain, Gonzague, Sureau, Camille, Chung, Raymond T., Lauer, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936758/
https://www.ncbi.nlm.nih.gov/pubmed/29761102
http://dx.doi.org/10.3389/fmed.2018.00097
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author Fusco, Dahlene N.
Ganova-Raeva, Lilia
Khudyakov, Yury
Punkova, Lili
Mohamed, Aisha
Cheon, Scarlett Se Yun
Koirala, Prapti
Andersson, Karin L.
Jourdain, Gonzague
Sureau, Camille
Chung, Raymond T.
Lauer, Georg
author_facet Fusco, Dahlene N.
Ganova-Raeva, Lilia
Khudyakov, Yury
Punkova, Lili
Mohamed, Aisha
Cheon, Scarlett Se Yun
Koirala, Prapti
Andersson, Karin L.
Jourdain, Gonzague
Sureau, Camille
Chung, Raymond T.
Lauer, Georg
author_sort Fusco, Dahlene N.
collection PubMed
description A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy.
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spelling pubmed-59367582018-05-14 Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy Fusco, Dahlene N. Ganova-Raeva, Lilia Khudyakov, Yury Punkova, Lili Mohamed, Aisha Cheon, Scarlett Se Yun Koirala, Prapti Andersson, Karin L. Jourdain, Gonzague Sureau, Camille Chung, Raymond T. Lauer, Georg Front Med (Lausanne) Medicine A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy. Frontiers Media S.A. 2018-04-30 /pmc/articles/PMC5936758/ /pubmed/29761102 http://dx.doi.org/10.3389/fmed.2018.00097 Text en Copyright © 2018 Fusco, Ganova-Raeva, Khudyakov, Punkova, Mohamed, Cheon, Koirala, Andersson, Jourdain, Sureau, Chung and Lauer. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Fusco, Dahlene N.
Ganova-Raeva, Lilia
Khudyakov, Yury
Punkova, Lili
Mohamed, Aisha
Cheon, Scarlett Se Yun
Koirala, Prapti
Andersson, Karin L.
Jourdain, Gonzague
Sureau, Camille
Chung, Raymond T.
Lauer, Georg
Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy
title Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy
title_full Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy
title_fullStr Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy
title_full_unstemmed Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy
title_short Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy
title_sort reactivation of a vaccine escape hepatitis b virus mutant in a cambodian patient during anti-hepatitis c virus therapy
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936758/
https://www.ncbi.nlm.nih.gov/pubmed/29761102
http://dx.doi.org/10.3389/fmed.2018.00097
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