Cargando…

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

Fatty liver disease (FLD) is a burgeoning health problem. A missense variant (I148M) in patatin-like phospholipase domain–containing protein 3 (PNPLA3) confers susceptibility to FLD, although the mechanism is not known. To glean first insights into the physiological function of PNPLA3, we performed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mitsche, Matthew A., Hobbs, Helen H., Cohen, Jonathan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Lipids
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936833/ https://www.ncbi.nlm.nih.gov/pubmed/29555681 http://dx.doi.org/10.1074/jbc.RA118.002333

Ejemplares similares

Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites
por: Hill, Ross J., et al.
Publicado: (2016)

The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain
por: Heier, Christoph, et al.
Publicado: (2017)

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
por: He, Shaoqing, et al.
Publicado: (2010)

Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP(2))
por: Nomikos, Michail, et al.
Publicado: (2015)

Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins
por: Smagris, Eriks, et al.
Publicado: (2016)

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
por: Huang, Yongcheng, et al.
Publicado: (2011)

Structure of a CGI-58 Motif Provides the Molecular Basis of Lipid Droplet Anchoring
por: Boeszoermenyi, Andras, et al.
Publicado: (2015)

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response
por: Ariyama, Hiroyuki, et al.
Publicado: (2010)

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate
por: Pribasnig, Maria A., et al.
Publicado: (2015)

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
por: Chandak, Prakash G., et al.
Publicado: (2010)

Homocysteine regulates fatty acid and lipid metabolism in yeast
por: Visram, Myriam, et al.
Publicado: (2018)

Distinct Roles of the Phosphatidate Phosphatases Lipin 1 and 2 during Adipogenesis and Lipid Droplet Biogenesis in 3T3-L1 Cells
por: Sembongi, Hiroshi, et al.
Publicado: (2013)

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation
por: Pajed, Laura, et al.
Publicado: (2019)

Phospholipid-esterified Eicosanoids Are Generated in Agonist-activated Human Platelets and Enhance Tissue Factor-dependent Thrombin Generation
por: Thomas, Christopher P., et al.
Publicado: (2010)

Novel Keto-phospholipids Are Generated by Monocytes and Macrophages, Detected in Cystic Fibrosis, and Activate Peroxisome Proliferator-activated Receptor-γ
por: Hammond, Victoria J., et al.
Publicado: (2012)

A Peptide Derived from G(0)/G(1) Switch Gene 2 Acts as Noncompetitive Inhibitor of Adipose Triglyceride Lipase
por: Cerk, Ines K., et al.
Publicado: (2014)

Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling
por: Hofer, Peter, et al.
Publicado: (2015)

Triglycerides and HDL Cholesterol: Stars or second leads in diabetes?
por: Bitzur, Rafael, et al.
Publicado: (2009)

Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women(1)(2)(3)
por: Lacroix, Émilie, et al.
Publicado: (2012)

Sphingolipid Domains in the Plasma Membranes of Fibroblasts Are Not Enriched with Cholesterol
por: Frisz, Jessica F., et al.
Publicado: (2013)

Kdo(2)-Lipid A, a TLR4-specific Agonist, Induces de Novo Sphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy
por: Sims, Kacee, et al.
Publicado: (2010)

Serum lipoprotein–derived fatty acids regulate hypoxia-inducible factor
por: Shao, Wei, et al.
Publicado: (2021)

Role of Patatin-Like Phospholipase Domain-Containing 3 on Lipid-Induced Hepatic Steatosis and Insulin Resistance in Rats
por: Kumashiro, Naoki, et al.
Publicado: (2013)

Functional and Topological Analysis of Yeast Acyl-CoA:Diacylglycerol Acyltransferase 2, an Endoplasmic Reticulum Enzyme Essential for Triacylglycerol Biosynthesis
por: Liu, Qin, et al.
Publicado: (2011)

The CDK9–cyclin T1 complex mediates saturated fatty acid–induced vascular calcification by inducing expression of the transcription factor CHOP
por: Shiozaki, Yuji, et al.
Publicado: (2018)

Lipid Raft Association and Cholesterol Sensitivity of P2X1-4 Receptors for ATP: CHIMERAS AND POINT MUTANTS IDENTIFY INTRACELLULAR AMINO-TERMINAL RESIDUES INVOLVED IN LIPID REGULATION OF P2X1 RECEPTORS
por: Allsopp, Rebecca C., et al.
Publicado: (2010)

The Endoplasmic Reticulum Coat Protein II Transport Machinery Coordinates Cellular Lipid Secretion and Cholesterol Biosynthesis
por: Fryer, Lee G. D., et al.
Publicado: (2014)

Transcription Factor Reb1p Regulates DGK1-encoded Diacylglycerol Kinase and Lipid Metabolism in Saccharomyces cerevisiae
por: Qiu, Yixuan, et al.
Publicado: (2013)

Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids
por: Joshi, Alaumy, et al.
Publicado: (2018)

Effect of lipid accumulation product on the development of hypertension among nondiabetic individuals in eastern China: A cross‐sectional study
por: Shu, Li, et al.
Publicado: (2023)

Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry
por: Wijesinghe, Kaveesha J., et al.
Publicado: (2017)

Effect of mastication on lipid bioaccessibility of almonds in a randomized human study and its implications for digestion kinetics, metabolizable energy, and postprandial lipemia(1)(2)(3)(4)
por: Grundy, Myriam ML, et al.
Publicado: (2015)

Gene polymorphisms of Patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin, leptin in diabetic obese patients
por: Aly, Omnia, et al.
Publicado: (2020)

DNA Methylation of Patatin-Like Phospholipase Domain-Containing Protein 6 Gene Contributes to the Risk of Intracranial Aneurysm in Males
por: Zhou, Shengjun, et al.
Publicado: (2022)

Association of patatin-like phospholipase domain-containing protein 3 gene polymorphisms with susceptibility of nonalcoholic fatty liver disease in a Han Chinese population
por: Song, Guohe, et al.
Publicado: (2016)

The influence of RS738409 I148M polymorphism of patatin-like phospholipase domain containing 3 gene on the susceptibility of non-alcoholic fatty liver disease
por: Akkiz, Hikmet, et al.
Publicado: (2021)

Interaction between the patatin‐like phospholipase domain‐containing protein 3 genotype and coffee drinking and the risk for acute alcoholic hepatitis
por: Liangpunsakul, Suthat, et al.
Publicado: (2017)

Patatin‐like phospholipase domain containing 3 variants differentially impact metabolic traits in individuals at high risk for cardiovascular events
por: Rüschenbaum, Sabrina, et al.
Publicado: (2018)

Identification of Plant-like Galactolipids in Chromera velia, a Photosynthetic Relative of Malaria Parasites
por: Botté, Cyrille Y., et al.
Publicado: (2011)

Purification, Identification, and Cloning of Lysoplasmalogenase, the Enzyme That Catalyzes Hydrolysis of the Vinyl Ether Bond of Lysoplasmalogen
por: Wu, Lai-Chu, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_a4tt272l5m5m0rqrfr95dglmjb