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Structural implications of hERG K(+) channel block by a high-affinity minimally structured blocker

Cardiac potassium channels encoded by human ether-à-go-go–related gene (hERG) are major targets for structurally diverse drugs associated with acquired long QT syndrome. This study characterized hERG channel inhibition by a minimally structured high-affinity hERG inhibitor, Cavalli-2, composed of th...

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Detalles Bibliográficos
Autores principales:	Helliwell, Matthew V., Zhang, Yihong, El Harchi, Aziza, Du, Chunyun, Hancox, Jules C., Dempsey, Christopher E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936838/ https://www.ncbi.nlm.nih.gov/pubmed/29545312 http://dx.doi.org/10.1074/jbc.RA117.000363

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