Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats

Observe the effect of lipid-lowering tablets on body weight, liver index and serum biochemical indexes of hyperlipidemia rats. The hyperlipidemia rat model was replicated successfully. Compared with the model group, high, medium and low dose lipid-lowering tablets group could significantly increase...

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Detalles Bibliográficos
Autores principales: Kong, Xuejun, Gao, Yanling, Geng, Xiuli, Xie, Guoqi, Hao, Shaojun, Li, Yan, Zhang, Zhengchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936974/
https://www.ncbi.nlm.nih.gov/pubmed/29740235
http://dx.doi.org/10.1016/j.sjbs.2017.12.002
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author Kong, Xuejun
Gao, Yanling
Geng, Xiuli
Xie, Guoqi
Hao, Shaojun
Li, Yan
Zhang, Zhengchen
author_facet Kong, Xuejun
Gao, Yanling
Geng, Xiuli
Xie, Guoqi
Hao, Shaojun
Li, Yan
Zhang, Zhengchen
author_sort Kong, Xuejun
collection PubMed
description Observe the effect of lipid-lowering tablets on body weight, liver index and serum biochemical indexes of hyperlipidemia rats. The hyperlipidemia rat model was replicated successfully. Compared with the model group, high, medium and low dose lipid-lowering tablets group could significantly increase the body weight of rats with hyperlipidemia (P < 0.01, P < 0.05); High and middle dose lipid-lowering tablets group could significantly reduce the liver index of high fat rat (P < 0.01); High, medium and low dose lipid-lowering tablets group could significantly decrease levels of TC, TG, LDL-C, AST, ALT, ALP, Y-GT in serum (P < 0.01, P < 0.05), and significantly increase the level of HDL-C (P < 0.01). Lipid-lowering tablets can effectively regulate the body lipid metabolism of rats, and have a certain therapeutic effect on hyperlipidemia.
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spelling pubmed-59369742018-05-08 Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats Kong, Xuejun Gao, Yanling Geng, Xiuli Xie, Guoqi Hao, Shaojun Li, Yan Zhang, Zhengchen Saudi J Biol Sci Article Observe the effect of lipid-lowering tablets on body weight, liver index and serum biochemical indexes of hyperlipidemia rats. The hyperlipidemia rat model was replicated successfully. Compared with the model group, high, medium and low dose lipid-lowering tablets group could significantly increase the body weight of rats with hyperlipidemia (P < 0.01, P < 0.05); High and middle dose lipid-lowering tablets group could significantly reduce the liver index of high fat rat (P < 0.01); High, medium and low dose lipid-lowering tablets group could significantly decrease levels of TC, TG, LDL-C, AST, ALT, ALP, Y-GT in serum (P < 0.01, P < 0.05), and significantly increase the level of HDL-C (P < 0.01). Lipid-lowering tablets can effectively regulate the body lipid metabolism of rats, and have a certain therapeutic effect on hyperlipidemia. Elsevier 2018-05 2017-12-05 /pmc/articles/PMC5936974/ /pubmed/29740235 http://dx.doi.org/10.1016/j.sjbs.2017.12.002 Text en © 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kong, Xuejun
Gao, Yanling
Geng, Xiuli
Xie, Guoqi
Hao, Shaojun
Li, Yan
Zhang, Zhengchen
Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats
title Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats
title_full Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats
title_fullStr Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats
title_full_unstemmed Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats
title_short Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats
title_sort effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936974/
https://www.ncbi.nlm.nih.gov/pubmed/29740235
http://dx.doi.org/10.1016/j.sjbs.2017.12.002
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