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The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review
BACKGROUND: Cell-free DNA (cfDNA) can be detected in the circulation of healthy individuals, but is found in higher concentrations in cancer patients. Furthermore, mutations in tumor cells can be identified in circulating DNA fragments. This has been the subject of significant interest in the field...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937025/ https://www.ncbi.nlm.nih.gov/pubmed/29761074 http://dx.doi.org/10.3389/fonc.2018.00132 |
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author | Fussey, Jonathan M. Bryant, Jennifer L. Batis, Nikolaos Spruce, Rachael J. Hartley, Andrew Good, James S. McCabe, Christopher J. Boelaert, Kristien Sharma, Neil Mehanna, Hisham |
author_facet | Fussey, Jonathan M. Bryant, Jennifer L. Batis, Nikolaos Spruce, Rachael J. Hartley, Andrew Good, James S. McCabe, Christopher J. Boelaert, Kristien Sharma, Neil Mehanna, Hisham |
author_sort | Fussey, Jonathan M. |
collection | PubMed |
description | BACKGROUND: Cell-free DNA (cfDNA) can be detected in the circulation of healthy individuals, but is found in higher concentrations in cancer patients. Furthermore, mutations in tumor cells can be identified in circulating DNA fragments. This has been the subject of significant interest in the field of cancer research, but little has been published in thyroid cancer. OBJECTIVES: To assess all available evidence on the use of circulating cfDNA in the diagnosis, management and surveillance of patients with differentiated thyroid cancer, and collate it into a systematic review to guide future research. METHODS: A comprehensive literature search on the measurement of cfDNA in thyroid cancer was undertaken, and results from relevant studies collated into a systematic review. RESULTS: Nine studies were identified, with varying methodologies and findings. Key techniques and findings are summarized. CONCLUSION: There is limited but promising evidence that somatic mutations in thyroid cancer can be detected in circulating cfDNA and are associated with more advanced disease. Further research is required to develop a clinically useful tool based on cfDNA to improve the management of thyroid cancers. |
format | Online Article Text |
id | pubmed-5937025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59370252018-05-14 The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review Fussey, Jonathan M. Bryant, Jennifer L. Batis, Nikolaos Spruce, Rachael J. Hartley, Andrew Good, James S. McCabe, Christopher J. Boelaert, Kristien Sharma, Neil Mehanna, Hisham Front Oncol Oncology BACKGROUND: Cell-free DNA (cfDNA) can be detected in the circulation of healthy individuals, but is found in higher concentrations in cancer patients. Furthermore, mutations in tumor cells can be identified in circulating DNA fragments. This has been the subject of significant interest in the field of cancer research, but little has been published in thyroid cancer. OBJECTIVES: To assess all available evidence on the use of circulating cfDNA in the diagnosis, management and surveillance of patients with differentiated thyroid cancer, and collate it into a systematic review to guide future research. METHODS: A comprehensive literature search on the measurement of cfDNA in thyroid cancer was undertaken, and results from relevant studies collated into a systematic review. RESULTS: Nine studies were identified, with varying methodologies and findings. Key techniques and findings are summarized. CONCLUSION: There is limited but promising evidence that somatic mutations in thyroid cancer can be detected in circulating cfDNA and are associated with more advanced disease. Further research is required to develop a clinically useful tool based on cfDNA to improve the management of thyroid cancers. Frontiers Media S.A. 2018-04-30 /pmc/articles/PMC5937025/ /pubmed/29761074 http://dx.doi.org/10.3389/fonc.2018.00132 Text en Copyright © 2018 Fussey, Bryant, Batis, Spruce, Hartley, Good, McCabe, Boelaert, Sharma and Mehanna. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Fussey, Jonathan M. Bryant, Jennifer L. Batis, Nikolaos Spruce, Rachael J. Hartley, Andrew Good, James S. McCabe, Christopher J. Boelaert, Kristien Sharma, Neil Mehanna, Hisham The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review |
title | The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review |
title_full | The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review |
title_fullStr | The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review |
title_full_unstemmed | The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review |
title_short | The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review |
title_sort | clinical utility of cell-free dna measurement in differentiated thyroid cancer: a systematic review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937025/ https://www.ncbi.nlm.nih.gov/pubmed/29761074 http://dx.doi.org/10.3389/fonc.2018.00132 |
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