A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

In Alzheimer’s disease (AD) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary tangles that are characteristic of these neurodegenerative diseases. Our previous work has demonstrated that the thousand-and-one amino acid kin...

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Detalles Bibliográficos
Autores principales: Giacomini, Caterina, Koo, Chuay-Yeng, Yankova, Natalia, Tavares, Ignatius A., Wray, Selina, Noble, Wendy, Hanger, Diane P., Morris, Jonathan D. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937037/
https://www.ncbi.nlm.nih.gov/pubmed/29730992
http://dx.doi.org/10.1186/s40478-018-0539-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937037/
https://www.ncbi.nlm.nih.gov/pubmed/29730992
http://dx.doi.org/10.1186/s40478-018-0539-8

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