Cargando…

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

In Alzheimer’s disease (AD) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary tangles that are characteristic of these neurodegenerative diseases. Our previous work has demonstrated that the thousand-and-one amino acid kin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giacomini, Caterina, Koo, Chuay-Yeng, Yankova, Natalia, Tavares, Ignatius A., Wray, Selina, Noble, Wendy, Hanger, Diane P., Morris, Jonathan D. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937037/ https://www.ncbi.nlm.nih.gov/pubmed/29730992 http://dx.doi.org/10.1186/s40478-018-0539-8

Ejemplares similares

Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation
por: Hanger, Diane P., et al.
Publicado: (2011)

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate
por: Bondulich, Marie K., et al.
Publicado: (2016)

The Importance of Tau Phosphorylation for Neurodegenerative Diseases
por: Noble, Wendy, et al.
Publicado: (2013)

Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy
por: Garwood, Claire J., et al.
Publicado: (2010)

Tau phosphorylation affects its axonal transport and degradation
por: Rodríguez-Martín, Teresa, et al.
Publicado: (2013)

TBK1 interacts with tau and enhances neurodegeneration in tauopathy
por: Abreha, Measho H., et al.
Publicado: (2021)

Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies
por: Rawat, Priyanka, et al.
Publicado: (2022)

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease
por: Lau, Dawn H. W., et al.
Publicado: (2016)

Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy
por: Lionnet, Arthur, et al.
Publicado: (2018)

Roles of tau protein in health and disease
por: Guo, Tong, et al.
Publicado: (2017)

VPS35 regulates tau phosphorylation and neuropathology in tauopathy
por: Vagnozzi, Alana N., et al.
Publicado: (2021)

Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models
por: Lacomme, Marine, et al.
Publicado: (2022)

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
por: Bailey, Rachel M., et al.
Publicado: (2013)

The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model
por: Stancu, Ilie Cosmin, et al.
Publicado: (2022)

Glial contributions to neurodegeneration in tauopathies
por: Leyns, Cheryl E. G., et al.
Publicado: (2017)

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
por: Šimić, Goran, et al.
Publicado: (2016)

Tauopathy and neurodegeneration: A role for stress
por: Sierra-Fonseca, Jorge A., et al.
Publicado: (2018)

Transcellular Spreading of Tau in Tauopathies
por: Demaegd, Koen, et al.
Publicado: (2018)

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture
por: Garwood, C J, et al.
Publicado: (2011)

Physiological release of endogenous tau is stimulated by neuronal activity
por: Pooler, Amy M, et al.
Publicado: (2013)

Inhibition of glycogen synthase kinase-3 by BTA-EG(4) reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease
por: Croft, Cara L., et al.
Publicado: (2017)

Astrocytes in Tauopathies
por: Reid, Matthew J., et al.
Publicado: (2020)

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response
por: Guo, Tong, et al.
Publicado: (2019)

The microtubule-associated protein tau is phosphorylated by Syk
por: Lebouvier, Thibaud, et al.
Publicado: (2008)

Plasma phosphorylated tau181 and neurodegeneration in Alzheimer’s disease
por: Hansson, Oskar, et al.
Publicado: (2020)

Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β
por: Povellato, Giulia, et al.
Publicado: (2013)

Are Tau Aggregates Toxic or Protective in Tauopathies?
por: Cowan, Catherine M., et al.
Publicado: (2013)

NMR Studies of Tau Protein in Tauopathies
por: Kitoka, Kristine, et al.
Publicado: (2021)

Threonine(175), a novel pathological phosphorylation site on tau protein linked to multiple tauopathies
por: Moszczynski, Alexander J., et al.
Publicado: (2017)

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
por: Brody, A. Harrison, et al.
Publicado: (2022)

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
por: Smith, Ethan D., et al.
Publicado: (2023)

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain
por: Kurbatskaya, Ksenia, et al.
Publicado: (2016)

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2021)

Autophagy impairment: a crossroad between neurodegeneration and tauopathies
por: Nassif, Melissa, et al.
Publicado: (2012)

Tau Phosphorylation in Female Neurodegeneration: Role of Estrogens, Progesterone, and Prolactin
por: Muñoz-Mayorga, Daniel, et al.
Publicado: (2018)

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
por: Zimmer-Bensch, Geraldine, et al.
Publicado: (2021)

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation
por: Ambegaokar, Surendra S., et al.
Publicado: (2011)

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2020)

Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies
por: Pires, Geoffrey, et al.
Publicado: (2019)

Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
por: Brody, A. Harrison, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_icpnm0lpsrriljplplvb5ra57e