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Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach

The most common malignant neoplasm of the head and neck region is laryngeal cancer which presents a significant international health problem. The present study aims to screen potential proteins related to laryngeal cancer by network analysis to further understanding disease pathogenesis and biomarke...

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Autores principales: Peyvandi, Hassan, Peyvandi, Ali Asghar, Safaei, Akram, Zamanian Azodi, Mona, Rezaei-Tavirani, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937111/
https://www.ncbi.nlm.nih.gov/pubmed/29755572
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author Peyvandi, Hassan
Peyvandi, Ali Asghar
Safaei, Akram
Zamanian Azodi, Mona
Rezaei-Tavirani, Mostafa
author_facet Peyvandi, Hassan
Peyvandi, Ali Asghar
Safaei, Akram
Zamanian Azodi, Mona
Rezaei-Tavirani, Mostafa
author_sort Peyvandi, Hassan
collection PubMed
description The most common malignant neoplasm of the head and neck region is laryngeal cancer which presents a significant international health problem. The present study aims to screen potential proteins related to laryngeal cancer by network analysis to further understanding disease pathogenesis and biomarker discovery. Differentially expressed proteins were extracted from literatures of laryngeal cancer that compare proteome profiling of patient›s tissue with healthy controls. The PPI network analyzed for up and down regulated proteins with Cytoscape Version 3.4. After PPI construction, topological properties of the two networks have been analyzed. Besides, by using MCODE. the Gene Ontology (GO) analysis, the related modules and pathways were examined. Our study screened 275 differentially changed proteins, including 136 up- and 139 down-regulated proteins. For each network, it has been considered 20 key proteins as hub and 20 as bottleneck. A number of 26 hub-bottleneck nodes is introduced for the two networks. A total of 11 modules including 6 downregulated and 5 upregulated network modules were obtained. The most significant GO function in the significant upregulated module was the RNA processing, and the most significant one in the downregulated module with highest score was the respiratory electron transport chain. Among 275 investigated proteins, 12 crucial proteins are determined that 4 of them can be introduce as a possible biomarker panel including YWHAZ, PPP2R1A, HSP90AA1, and CALM3 for human laryngeal cancer.
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spelling pubmed-59371112018-05-11 Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach Peyvandi, Hassan Peyvandi, Ali Asghar Safaei, Akram Zamanian Azodi, Mona Rezaei-Tavirani, Mostafa Iran J Pharm Res Original Article The most common malignant neoplasm of the head and neck region is laryngeal cancer which presents a significant international health problem. The present study aims to screen potential proteins related to laryngeal cancer by network analysis to further understanding disease pathogenesis and biomarker discovery. Differentially expressed proteins were extracted from literatures of laryngeal cancer that compare proteome profiling of patient›s tissue with healthy controls. The PPI network analyzed for up and down regulated proteins with Cytoscape Version 3.4. After PPI construction, topological properties of the two networks have been analyzed. Besides, by using MCODE. the Gene Ontology (GO) analysis, the related modules and pathways were examined. Our study screened 275 differentially changed proteins, including 136 up- and 139 down-regulated proteins. For each network, it has been considered 20 key proteins as hub and 20 as bottleneck. A number of 26 hub-bottleneck nodes is introduced for the two networks. A total of 11 modules including 6 downregulated and 5 upregulated network modules were obtained. The most significant GO function in the significant upregulated module was the RNA processing, and the most significant one in the downregulated module with highest score was the respiratory electron transport chain. Among 275 investigated proteins, 12 crucial proteins are determined that 4 of them can be introduce as a possible biomarker panel including YWHAZ, PPP2R1A, HSP90AA1, and CALM3 for human laryngeal cancer. Shaheed Beheshti University of Medical Sciences 2018 /pmc/articles/PMC5937111/ /pubmed/29755572 Text en © 2018 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Peyvandi, Hassan
Peyvandi, Ali Asghar
Safaei, Akram
Zamanian Azodi, Mona
Rezaei-Tavirani, Mostafa
Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach
title Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach
title_full Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach
title_fullStr Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach
title_full_unstemmed Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach
title_short Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach
title_sort introducing potential key proteins and pathways in human laryngeal cancer: a system biology approach
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937111/
https://www.ncbi.nlm.nih.gov/pubmed/29755572
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