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Early morphea simulating patch-stage mycosis fungoides in two cases

Morphea is a skin disorder characterized by thickening of dermis and subcutaneous tissues and loss of adnexal structures. In the early inflammatory stage of morphea, diagnostic histological findings are absent and this may lead to confusion with other inflammatory dermatoses such as mycosis fungoide...

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Autores principales: Basir, Hamid R. Ghasemi, Alirezaei, Pedram, Rezanejad, Aliasghar, Daneshyar, Sajjad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937215/
https://www.ncbi.nlm.nih.gov/pubmed/29760873
http://dx.doi.org/10.4081/dr.2018.7477
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author Basir, Hamid R. Ghasemi
Alirezaei, Pedram
Rezanejad, Aliasghar
Daneshyar, Sajjad
author_facet Basir, Hamid R. Ghasemi
Alirezaei, Pedram
Rezanejad, Aliasghar
Daneshyar, Sajjad
author_sort Basir, Hamid R. Ghasemi
collection PubMed
description Morphea is a skin disorder characterized by thickening of dermis and subcutaneous tissues and loss of adnexal structures. In the early inflammatory stage of morphea, diagnostic histological findings are absent and this may lead to confusion with other inflammatory dermatoses such as mycosis fungoides (MF). We report two cases of early stage morphea mimicking patchstage of MF. Histopathologic examination of biopsies obtained early in the disease course revealed lymphocytic epidermotropism arranged in small pautrier-like collections as well as linear arrangements in dermal- epidermal junction. Additional biopsies were performed which revealed replacement of subcutaneous fat with closely packed thick collagen bundles under eccrine glands. This report points toward the fact that early stage morphea can simulate MF. Therefore additional evaluation is sometimes required for definite diagnosis.
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spelling pubmed-59372152018-05-14 Early morphea simulating patch-stage mycosis fungoides in two cases Basir, Hamid R. Ghasemi Alirezaei, Pedram Rezanejad, Aliasghar Daneshyar, Sajjad Dermatol Reports Case Report Morphea is a skin disorder characterized by thickening of dermis and subcutaneous tissues and loss of adnexal structures. In the early inflammatory stage of morphea, diagnostic histological findings are absent and this may lead to confusion with other inflammatory dermatoses such as mycosis fungoides (MF). We report two cases of early stage morphea mimicking patchstage of MF. Histopathologic examination of biopsies obtained early in the disease course revealed lymphocytic epidermotropism arranged in small pautrier-like collections as well as linear arrangements in dermal- epidermal junction. Additional biopsies were performed which revealed replacement of subcutaneous fat with closely packed thick collagen bundles under eccrine glands. This report points toward the fact that early stage morphea can simulate MF. Therefore additional evaluation is sometimes required for definite diagnosis. PAGEPress Publications, Pavia, Italy 2018-04-23 /pmc/articles/PMC5937215/ /pubmed/29760873 http://dx.doi.org/10.4081/dr.2018.7477 Text en ©Copyright H.R. Ghasemi Basir et al., 2018 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Basir, Hamid R. Ghasemi
Alirezaei, Pedram
Rezanejad, Aliasghar
Daneshyar, Sajjad
Early morphea simulating patch-stage mycosis fungoides in two cases
title Early morphea simulating patch-stage mycosis fungoides in two cases
title_full Early morphea simulating patch-stage mycosis fungoides in two cases
title_fullStr Early morphea simulating patch-stage mycosis fungoides in two cases
title_full_unstemmed Early morphea simulating patch-stage mycosis fungoides in two cases
title_short Early morphea simulating patch-stage mycosis fungoides in two cases
title_sort early morphea simulating patch-stage mycosis fungoides in two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937215/
https://www.ncbi.nlm.nih.gov/pubmed/29760873
http://dx.doi.org/10.4081/dr.2018.7477
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