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Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC) are primary liver cancers where all or most of the tumor burden is usually confined to the liver. Therefore, locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease with minimal systemic...

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Autores principales: Kis, Bela, El-Haddad, Ghassan, Sheth, Rahul A., Parikh, Nainesh S., Ganguli, Suvranu, Shyn, Paul B., Choi, Junsung, Brown, Karen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937250/
https://www.ncbi.nlm.nih.gov/pubmed/28975829
http://dx.doi.org/10.1177/1073274817729244
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author Kis, Bela
El-Haddad, Ghassan
Sheth, Rahul A.
Parikh, Nainesh S.
Ganguli, Suvranu
Shyn, Paul B.
Choi, Junsung
Brown, Karen T.
author_facet Kis, Bela
El-Haddad, Ghassan
Sheth, Rahul A.
Parikh, Nainesh S.
Ganguli, Suvranu
Shyn, Paul B.
Choi, Junsung
Brown, Karen T.
author_sort Kis, Bela
collection PubMed
description Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC) are primary liver cancers where all or most of the tumor burden is usually confined to the liver. Therefore, locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease with minimal systemic side effects. The English medical literature and clinical trials were reviewed to provide a synopsis on the available liver-directed percutaneous therapies for HCC and IHC. Locoregional liver-directed therapies provide survival benefit for patients with HCC and IHC compared to best medical treatment and have lower comorbid risks compared to surgical resection. These treatment options should be considered, especially in patients with unresectable disease.
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spelling pubmed-59372502018-05-16 Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma Kis, Bela El-Haddad, Ghassan Sheth, Rahul A. Parikh, Nainesh S. Ganguli, Suvranu Shyn, Paul B. Choi, Junsung Brown, Karen T. Cancer Control Review Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC) are primary liver cancers where all or most of the tumor burden is usually confined to the liver. Therefore, locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease with minimal systemic side effects. The English medical literature and clinical trials were reviewed to provide a synopsis on the available liver-directed percutaneous therapies for HCC and IHC. Locoregional liver-directed therapies provide survival benefit for patients with HCC and IHC compared to best medical treatment and have lower comorbid risks compared to surgical resection. These treatment options should be considered, especially in patients with unresectable disease. SAGE Publications 2017-09-07 /pmc/articles/PMC5937250/ /pubmed/28975829 http://dx.doi.org/10.1177/1073274817729244 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Kis, Bela
El-Haddad, Ghassan
Sheth, Rahul A.
Parikh, Nainesh S.
Ganguli, Suvranu
Shyn, Paul B.
Choi, Junsung
Brown, Karen T.
Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
title Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
title_full Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
title_fullStr Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
title_full_unstemmed Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
title_short Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
title_sort liver-directed therapies for hepatocellular carcinoma and intrahepatic cholangiocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937250/
https://www.ncbi.nlm.nih.gov/pubmed/28975829
http://dx.doi.org/10.1177/1073274817729244
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