Cargando…
Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis
Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived mesenchymal stem cells (GMSC) have shown anti-inflammatory and immunomodulatory effects on autoimmune and inflammatory...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937358/ https://www.ncbi.nlm.nih.gov/pubmed/29760701 http://dx.doi.org/10.3389/fimmu.2018.00878 |
_version_ | 1783320613010538496 |
---|---|
author | Zhang, Ximei Huang, Feng Li, Weixuan Dang, Jun-long Yuan, Jia Wang, Julie Zeng, Dong-Lan Sun, Can-Xing Liu, Yan-Ying Ao, Qian Tan, Hongmei Su, Wenru Qian, Xiaoxian Olsen, Nancy Zheng, Song Guo |
author_facet | Zhang, Ximei Huang, Feng Li, Weixuan Dang, Jun-long Yuan, Jia Wang, Julie Zeng, Dong-Lan Sun, Can-Xing Liu, Yan-Ying Ao, Qian Tan, Hongmei Su, Wenru Qian, Xiaoxian Olsen, Nancy Zheng, Song Guo |
author_sort | Zhang, Ximei |
collection | PubMed |
description | Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived mesenchymal stem cells (GMSC) have shown anti-inflammatory and immunomodulatory effects on autoimmune and inflammatory diseases. However, the function of GMSC in controlling atherosclerosis is far from clear. The present study is aimed to elucidate the role of GMSC in atherosclerosis, examining the inhibition of GMSC on macrophage foam cell formation, and further determining whether GMSC could affect the polarization and activation of macrophages under different conditions. The results show that infusion of GMSC to AopE(−/−) mice significantly reduced the frequency of inflammatory monocytes/macrophages and decreased the plaque size and lipid deposition. Additionally, GMSC treatment markedly inhibited macrophage foam cell formation and reduced inflammatory macrophage activation, converting inflammatory macrophages to anti-inflammatory macrophages in vitro. Thus, our study has revealed a significant role of GMSC on modulating inflammatory monocytes/macrophages and alleviating atherosclerosis. |
format | Online Article Text |
id | pubmed-5937358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59373582018-05-14 Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis Zhang, Ximei Huang, Feng Li, Weixuan Dang, Jun-long Yuan, Jia Wang, Julie Zeng, Dong-Lan Sun, Can-Xing Liu, Yan-Ying Ao, Qian Tan, Hongmei Su, Wenru Qian, Xiaoxian Olsen, Nancy Zheng, Song Guo Front Immunol Immunology Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived mesenchymal stem cells (GMSC) have shown anti-inflammatory and immunomodulatory effects on autoimmune and inflammatory diseases. However, the function of GMSC in controlling atherosclerosis is far from clear. The present study is aimed to elucidate the role of GMSC in atherosclerosis, examining the inhibition of GMSC on macrophage foam cell formation, and further determining whether GMSC could affect the polarization and activation of macrophages under different conditions. The results show that infusion of GMSC to AopE(−/−) mice significantly reduced the frequency of inflammatory monocytes/macrophages and decreased the plaque size and lipid deposition. Additionally, GMSC treatment markedly inhibited macrophage foam cell formation and reduced inflammatory macrophage activation, converting inflammatory macrophages to anti-inflammatory macrophages in vitro. Thus, our study has revealed a significant role of GMSC on modulating inflammatory monocytes/macrophages and alleviating atherosclerosis. Frontiers Media S.A. 2018-04-30 /pmc/articles/PMC5937358/ /pubmed/29760701 http://dx.doi.org/10.3389/fimmu.2018.00878 Text en Copyright © 2018 Zhang, Huang, Li, Dang, Yuan, Wang, Zeng, Sun, Liu, Ao, Tan, Su, Qian, Olsen and Zheng. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhang, Ximei Huang, Feng Li, Weixuan Dang, Jun-long Yuan, Jia Wang, Julie Zeng, Dong-Lan Sun, Can-Xing Liu, Yan-Ying Ao, Qian Tan, Hongmei Su, Wenru Qian, Xiaoxian Olsen, Nancy Zheng, Song Guo Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis |
title | Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis |
title_full | Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis |
title_fullStr | Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis |
title_full_unstemmed | Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis |
title_short | Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis |
title_sort | human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937358/ https://www.ncbi.nlm.nih.gov/pubmed/29760701 http://dx.doi.org/10.3389/fimmu.2018.00878 |
work_keys_str_mv | AT zhangximei humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT huangfeng humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT liweixuan humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT dangjunlong humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT yuanjia humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT wangjulie humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT zengdonglan humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT suncanxing humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT liuyanying humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT aoqian humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT tanhongmei humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT suwenru humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT qianxiaoxian humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT olsennancy humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis AT zhengsongguo humangingivaderivedmesenchymalstemcellsmodulatemonocytesmacrophagesandalleviateatherosclerosis |