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Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature

Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy. We present 13 cases diagnosed at two centers in Budapest and review the current literature. The majority of our cases presented with high-risk featur...

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Autores principales: Varga, Gergely, Mikala, Gábor, Gopcsa, László, Csukly, Zoltán, Kollai, Sarolta, Balázs, György, Botond, Tímár, Wohner, Nikolett, Horváth, Laura, Szombath, Gergely, Farkas, Péter, Masszi, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937370/
https://www.ncbi.nlm.nih.gov/pubmed/29849629
http://dx.doi.org/10.1155/2018/3970169
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author Varga, Gergely
Mikala, Gábor
Gopcsa, László
Csukly, Zoltán
Kollai, Sarolta
Balázs, György
Botond, Tímár
Wohner, Nikolett
Horváth, Laura
Szombath, Gergely
Farkas, Péter
Masszi, Tamás
author_facet Varga, Gergely
Mikala, Gábor
Gopcsa, László
Csukly, Zoltán
Kollai, Sarolta
Balázs, György
Botond, Tímár
Wohner, Nikolett
Horváth, Laura
Szombath, Gergely
Farkas, Péter
Masszi, Tamás
author_sort Varga, Gergely
collection PubMed
description Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy. We present 13 cases diagnosed at two centers in Budapest and review the current literature. The majority of our cases presented with high-risk features initially; two had plasma cell leukemia. Repeated genetic tests showed clonal evolution in 3 cases. Treatments varied according to the era, and efficacy was poor as generally reported in the literature. Only one patient is currently alive, with 3-month follow-up, and the patient responded to daratumumab-based treatment. Recent case reports show promising effectivity of pomalidomide and marizomib.
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spelling pubmed-59373702018-05-30 Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature Varga, Gergely Mikala, Gábor Gopcsa, László Csukly, Zoltán Kollai, Sarolta Balázs, György Botond, Tímár Wohner, Nikolett Horváth, Laura Szombath, Gergely Farkas, Péter Masszi, Tamás J Oncol Review Article Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy. We present 13 cases diagnosed at two centers in Budapest and review the current literature. The majority of our cases presented with high-risk features initially; two had plasma cell leukemia. Repeated genetic tests showed clonal evolution in 3 cases. Treatments varied according to the era, and efficacy was poor as generally reported in the literature. Only one patient is currently alive, with 3-month follow-up, and the patient responded to daratumumab-based treatment. Recent case reports show promising effectivity of pomalidomide and marizomib. Hindawi 2018-04-23 /pmc/articles/PMC5937370/ /pubmed/29849629 http://dx.doi.org/10.1155/2018/3970169 Text en Copyright © 2018 Gergely Varga et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Varga, Gergely
Mikala, Gábor
Gopcsa, László
Csukly, Zoltán
Kollai, Sarolta
Balázs, György
Botond, Tímár
Wohner, Nikolett
Horváth, Laura
Szombath, Gergely
Farkas, Péter
Masszi, Tamás
Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature
title Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature
title_full Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature
title_fullStr Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature
title_full_unstemmed Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature
title_short Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature
title_sort multiple myeloma of the central nervous system: 13 cases and review of the literature
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937370/
https://www.ncbi.nlm.nih.gov/pubmed/29849629
http://dx.doi.org/10.1155/2018/3970169
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