14-3-3 Proteins in Glutamatergic Synapses

The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and...

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Detalles Bibliográficos
Autores principales: Zhang, Jiajing, Zhou, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937437/
https://www.ncbi.nlm.nih.gov/pubmed/29849571
http://dx.doi.org/10.1155/2018/8407609
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author Zhang, Jiajing
Zhou, Yi
author_facet Zhang, Jiajing
Zhou, Yi
author_sort Zhang, Jiajing
collection PubMed
description The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.
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spelling pubmed-59374372018-05-30 14-3-3 Proteins in Glutamatergic Synapses Zhang, Jiajing Zhou, Yi Neural Plast Review Article The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions. Hindawi 2018-04-23 /pmc/articles/PMC5937437/ /pubmed/29849571 http://dx.doi.org/10.1155/2018/8407609 Text en Copyright © 2018 Jiajing Zhang and Yi Zhou. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Jiajing
Zhou, Yi
14-3-3 Proteins in Glutamatergic Synapses
title 14-3-3 Proteins in Glutamatergic Synapses
title_full 14-3-3 Proteins in Glutamatergic Synapses
title_fullStr 14-3-3 Proteins in Glutamatergic Synapses
title_full_unstemmed 14-3-3 Proteins in Glutamatergic Synapses
title_short 14-3-3 Proteins in Glutamatergic Synapses
title_sort 14-3-3 proteins in glutamatergic synapses
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937437/
https://www.ncbi.nlm.nih.gov/pubmed/29849571
http://dx.doi.org/10.1155/2018/8407609
work_keys_str_mv AT zhangjiajing 1433proteinsinglutamatergicsynapses
AT zhouyi 1433proteinsinglutamatergicsynapses

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