Cargando…

Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study

INTRODUCTION: Coeliac disease (CD) and immune thrombocytopenic purpura (ITP) are immune conditions, often associated with other immune disorders. In recent years, increasing attention has been directed towards the association between ITP and CD. AIM: To investigate the frequency of ITP in CD patient...

Descripción completa

Detalles Bibliográficos
Autores principales: Bibbò, Stefano, Fozza, Claudio, Pes, Giovanni Mario, Rojas, Rodrigo, Manetti, Roberto, Dore, Maria Pina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937450/
https://www.ncbi.nlm.nih.gov/pubmed/29849587
http://dx.doi.org/10.1155/2018/4138434
_version_ 1783320629444870144
author Bibbò, Stefano
Fozza, Claudio
Pes, Giovanni Mario
Rojas, Rodrigo
Manetti, Roberto
Dore, Maria Pina
author_facet Bibbò, Stefano
Fozza, Claudio
Pes, Giovanni Mario
Rojas, Rodrigo
Manetti, Roberto
Dore, Maria Pina
author_sort Bibbò, Stefano
collection PubMed
description INTRODUCTION: Coeliac disease (CD) and immune thrombocytopenic purpura (ITP) are immune conditions, often associated with other immune disorders. In recent years, increasing attention has been directed towards the association between ITP and CD. AIM: To investigate the frequency of ITP in CD patients and vice versa and to assess the risk of their association. PATIENTS AND METHODS: This was a prospective observational study. All consecutive patients with CD or ITP attending our department were enrolled between January 2016 and December 2017. All patients with CD were screened for ITP and patients with ITP for CD. Odds ratios (ORs) were calculated based on the prevalence in the general population. RESULTS: Two hundred sixty-one CD patients (212 female, mean age 47 ± 16.1 years) and 32 ITP patients (17 female, mean age 57.8 ± 17.4 years) were enrolled. In the CD cohort, two patients (2/261; 0.8%) reported a previous diagnosis of ITP, compared to the general population; OR was 15.3 (95% CI, 3.82–61.73; p < 0.0001). Similarly, in the ITP cohort, two patients (2/32; 6.3%) had a previous diagnosis of CD (OR: 9.89, 95% CI, 2.27–43.16; p = 0.0002). DISCUSSION: A greater frequency of ITP in coeliac patients and vice versa was observed in our study, suggesting an increased risk for patients of developing both disorders.
format Online
Article
Text
id pubmed-5937450
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-59374502018-05-30 Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study Bibbò, Stefano Fozza, Claudio Pes, Giovanni Mario Rojas, Rodrigo Manetti, Roberto Dore, Maria Pina Gastroenterol Res Pract Research Article INTRODUCTION: Coeliac disease (CD) and immune thrombocytopenic purpura (ITP) are immune conditions, often associated with other immune disorders. In recent years, increasing attention has been directed towards the association between ITP and CD. AIM: To investigate the frequency of ITP in CD patients and vice versa and to assess the risk of their association. PATIENTS AND METHODS: This was a prospective observational study. All consecutive patients with CD or ITP attending our department were enrolled between January 2016 and December 2017. All patients with CD were screened for ITP and patients with ITP for CD. Odds ratios (ORs) were calculated based on the prevalence in the general population. RESULTS: Two hundred sixty-one CD patients (212 female, mean age 47 ± 16.1 years) and 32 ITP patients (17 female, mean age 57.8 ± 17.4 years) were enrolled. In the CD cohort, two patients (2/261; 0.8%) reported a previous diagnosis of ITP, compared to the general population; OR was 15.3 (95% CI, 3.82–61.73; p < 0.0001). Similarly, in the ITP cohort, two patients (2/32; 6.3%) had a previous diagnosis of CD (OR: 9.89, 95% CI, 2.27–43.16; p = 0.0002). DISCUSSION: A greater frequency of ITP in coeliac patients and vice versa was observed in our study, suggesting an increased risk for patients of developing both disorders. Hindawi 2018-04-23 /pmc/articles/PMC5937450/ /pubmed/29849587 http://dx.doi.org/10.1155/2018/4138434 Text en Copyright © 2018 Stefano Bibbò et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bibbò, Stefano
Fozza, Claudio
Pes, Giovanni Mario
Rojas, Rodrigo
Manetti, Roberto
Dore, Maria Pina
Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study
title Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study
title_full Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study
title_fullStr Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study
title_full_unstemmed Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study
title_short Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study
title_sort increased frequency of immune thrombocytopenic purpura in coeliac disease and vice versa: a prospective observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937450/
https://www.ncbi.nlm.nih.gov/pubmed/29849587
http://dx.doi.org/10.1155/2018/4138434
work_keys_str_mv AT bibbostefano increasedfrequencyofimmunethrombocytopenicpurpuraincoeliacdiseaseandviceversaaprospectiveobservationalstudy
AT fozzaclaudio increasedfrequencyofimmunethrombocytopenicpurpuraincoeliacdiseaseandviceversaaprospectiveobservationalstudy
AT pesgiovannimario increasedfrequencyofimmunethrombocytopenicpurpuraincoeliacdiseaseandviceversaaprospectiveobservationalstudy
AT rojasrodrigo increasedfrequencyofimmunethrombocytopenicpurpuraincoeliacdiseaseandviceversaaprospectiveobservationalstudy
AT manettiroberto increasedfrequencyofimmunethrombocytopenicpurpuraincoeliacdiseaseandviceversaaprospectiveobservationalstudy
AT doremariapina increasedfrequencyofimmunethrombocytopenicpurpuraincoeliacdiseaseandviceversaaprospectiveobservationalstudy